use of linagliptin and pharmaceutical composition comprising linagliptin and long-acting basal insul

专利摘要:
DIABETES THERAPY. The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.
公开号:BR112012032579B1
申请号:R112012032579-5
申请日:2011-06-22
公开日:2021-05-11
发明作者:Thomas Klein；Michael Mark；Leo Thomas
申请人:Boehringer Ingelheim International Gmbh；
IPC主号:

专利说明:

The present invention relates to methods for treating and/or preventing metabolic diseases, especially type 2 diabetes mellitus and/or conditions related thereto (e.g. diabetic complications) comprising combined administration of long-acting insulin (such as, by example, insulin glargine or insulin detemir) and a certain DPP-4 inhibitor, to pharmaceutical compositions and combinations comprising such active components, and for certain therapeutic uses thereof.
In addition, the present invention relates to a method for improving glycemic control and/or prevention, reducing risk, reducing progression, delaying the onset or treatment of complications of diabetes mellitus, such as micro- and macrovascular diseases (by example, diabetic nephropathy, retinopathy or neuropathy, or brain- or cardiovascular complications, such as, for example, myocardial infarction, stroke or vascular death or hospitalization), in a patient in need thereof (type 1 diabetes patient, LADA or, particularly type 2 diabetes comprising combined administration (for example separate, simultaneous or sequential) of a long acting insulin (such as for example insulin glargine or insulin detemir) and a certain DPP-4 inhibitor.
Furthermore, the present invention relates to a certain DPP-4 inhibitor for subcutaneous or transdermal (systemic) therapeutic use, particularly in treatment and/or prevention of the metabolic diseases described in this application.
Furthermore, the present invention relates to a certain DPP-4 inhibitor for subcutaneous administration (particularly for subcutaneous injection), e.g., once a day, every other day, three times a week, twice a week or once a week, preferably less than once a day.
Furthermore, the present invention relates to a certain DPP-4 inhibitor for transdermal administration, for example, once a day, alternate days, three times a week, twice a week or once a week, preferably less than once a week. that once a day.
Furthermore, the present invention relates to a parenteral (preferably subcutaneous) delivery device, preferably a subcutaneous injection device, which can be with or without a needle (e.g. a needle-based pen injector or a jet/jet injector needleless), containing long-acting insulin and a certain DPP-4 inhibitor, and optionally one or more pharmaceutically acceptable carriers and/or diluents.
Furthermore, the present invention relates to a transdermal delivery device (e.g., a transdermal patch or gel) containing long-acting insulin and a certain DPP-4 inhibitor and, optionally, one or more vehicles. and/or pharmaceutically acceptable diluents.
Furthermore, the present invention relates to long acting DPP-4 and/or insulin inhibitors, each as defined in this application, for use in the combination therapies as described in this application.
Type 2 diabetes mellitus is a common chronic and progressive disease that results from a complex pathophysiology involving the dual endocrine effects of insulin resistance and impaired insulin secretion with the consequence that it does not meet the necessary demands for maintenance of patients. plasma glucose levels in the normal range. This leads to chronic hyperglycemia and its associated micro- and macrovascular complications or associated chronic damage, such as, for example, diabetic nephropathy, retinopathy or neuropathy, or macrovascular complications (eg, cardio- or cerebrovascular). The vascular disease component plays a significant role, but it is not the only factor in the spectrum of disorders associated with diabetes. The high frequency of complications leads to a significant reduction in life expectancy. Diabetes is currently the most frequent cause of adult-onset vision loss, kidney failure, and amputation in the Industrialized World because of diabetes-induced complications associated with a two- to five-fold increase in the risk of cardiovascular disease.
Treatment of type 2 diabetes typically begins with diet and exercise, followed by oral antidiabetic monotherapy, and although conventional monotherapy may initially control blood glucose in some patients, it is nevertheless associated with a high rate of secondary failure. The limitations of single-agent therapy to maintain glycemic control can be overcome, at least in some patients, and for a limited period of time by combining multiple drugs to achieve blood glucose reductions that cannot be sustained during long-term therapy. term with single agents. Available data support the conclusion that in most patients current monotherapy for type 2 diabetes will fail and multiple drug treatment will be required. But since type 2 diabetes is a progressive disease, even patients with good initial responses to conventional combination therapy will consequently require an increase in dosage or additional insulin treatment because the blood glucose level is very difficult to keep stable for a long period. of time. While existing combination therapy has the potential to increase glycemic control, it is not without limitations (especially in terms of long-term efficacy). Furthermore, traditional therapies may show an increased risk of side effects, such as hypoglycemia or weight gain, which can compromise their effectiveness and acceptability.
Thus, for many patients, these existing drug therapies result in progressive deterioration in metabolic control despite treatment and do not sufficiently control metabolic status especially over the long term and thus fail to achieve and maintain glycemic control in type 2 diabetes. advanced or late stage diabetes, including diabetes with inadequate glycemic control despite conventional oral or non-oral antidiabetic medication.
Therefore, although intensive treatment of hyperglycemia can reduce the incidence of chronic damage, many patients with type 2 diabetes remain inadequately treated, in part because of limitations in the long-term efficacy, tolerability, and dosage discomfort of conventional antihyperglycemic therapies .
This high incidence of therapeutic failure is a major contributor to the high rate of complications associated with long-term hyperglycemia or chronic damage (including micro- and macrovascular complications such as, for example, diabetic nephropathy, retinopathy or neuropathy, or brain-or complications cardiovascular diseases, such as, for example, myocardial infarction, stroke or death) in patients with type 2 diabetes.
Oral antidiabetic drugs conventionally used in therapy (such as, for example, first- or second-line, and/or mono- or (initial or complementary) combination therapy) include, but are not limited to, metformin, sulphonylureas, thiazolidinediones , glinides and α-glycosidase inhibitors.
Non-oral (typically injected) antidiabetic drugs conventionally used in therapy (such as, for example, first- or second-line, and/or mono- or (initial or complementary) combination therapy) include, without being restricted to these, GLP-1 or GLP-1 analogues, and insulin or insulin analogues.
However, the use of this antidiabetic or conventional antihyperglycemic agents may be associated with several adverse effects. For example, metformin may be associated with lactic acidosis or gastrointestinal side effects; sulfonylureas, glinides and insulin or insulin analogues may be associated with weight gain and hypoglycemia; thiazolidinediones may be associated with edema, bone cleft, weight gain, and heart failure/cardiac effects; and alpha-glycosidase blockers and GLP-1 or GLP-1 analogues may be associated with gastrointestinal adverse effects (eg, dyspepsia, flatulence or diarrhea, or nausea or vomiting).
Therefore, there remains a need in the art to provide effective, safe and tolerable antidiabetic therapies.
Furthermore, within type 2 diabetes therapy, it is a necessity to treat the condition effectively, avoiding the complications inherent in the condition, and delaying disease progression.
Furthermore, within type 2 diabetes therapy, there is a need for sustained improvements in the diabetic phenotype, glycemic and/or metabolic control, and/or glucose (blood) profile (preferably during the long term and/or during the chronic treatment).
In addition, there remains a need that antidiabetic treatments not only prevent the long-term complications often found in advanced stages of diabetes, but are also a therapeutic option in those diabetes patients who have developed or are at risk for complications from diabetes. development, such as renal failure.
Furthermore, there remains a need to provide prevention or reduction in the risk of adverse effects associated with conventional antidiabetic therapies.
The enzyme DPP-4 (dipeptidyl peptidase IV) also known as CD26 is a serine protease known to lead to the cleavage of a dipeptide at the N-terminal end of several proteins having a proline or alanine residue at its N-terminal end. Due to this property, DPP-4 inhibitors interfere with the plasma level of bioactive peptides including the GLP-1 peptide and are considered to be promising drugs for the treatment of diabetes mellitus.
For example, DPP-4 inhibitors and their uses are described in WO 2002/068420, WO 2004/018467, WO 2004/018468, WO 2004/018469, WO 2004/041820, WO 2004/046148, WO 2005/051950, WO 2005/082906, WO 2005/063750, WO 2005/085246, WO 2006/027204, WO 2006/029769, W02007/014886; WO 2004/050658, WO 2004/111051, WO 2005/058901, WO 2005/097798; WO 2006/068163, WO 2007/071738, WO 2008/017670; WO 2007/128721, WO 2007/128724, WO 2007/128761, or WO 2009/121945.
Long acting insulin within the meaning of this invention refers to an insulin or insulin analogue formulation which normally starts to work within approximately 1 to 6 hours and is normally effective for up to 24 hours or more (per example, up to 36 hours). Long acting insulin typically provides a continuous level of insulin activity (for up to 24 to 36 hours) and typically operates at maximum strength (with the flat action profile) after approximately 8 to 12 hours, sometimes longer. Long-acting insulin is usually given in the morning or before bed. Examples of long acting insulin may include, but are not limited to, insulin glargine, insulin detemir or insulin degludec, which are insulin analogues, and ultralenta insulin, which is regular human insulin formulated for slow absorption. Long-acting insulin is adjusted to meet baseline insulin requirements, as opposed to prandial insulin requirements (eg, to control hyperglycaemia). Long-acting insulin can typically be given ranging from twice or once a day, three times a week to once a week (extreme long-acting insulin). The route of insulin administration may include, but is not limited to, invasive delivery (such as, for example, via the parenteral route, preferably via subcutaneous injection) or non-invasive delivery (such as, for example, orally, buccal/sublingually , pulmonary, intranasal, or transdermal (eg, via iontophoresis, sonophoresis, or vesicular vehicles)), with subcutaneously injectable long-acting insulin being preferred.
In one embodiment, the long-acting insulin of this invention refers to any basal insulin known in the art, preferably having a basal release profile. A basal release profile refers to the kinetics, amount and rate of release of the insulin or insulin analogue from the formulation into a patient's systemic circulation. On a graph of the patient's mean plasma insulin levels over time, a basal release profile typically has a minimal peak (often referred to as "a no-peak profile" or "flat profile") and slowly and continuously releases insulin over time. an extended period of time.
In an additional embodiment, long-acting insulin is an acylated derivative of human insulin. Acylated insulin derivatives can be such in which a lipophilic group is attached to the lysine residue at position B29. A commercial product is Levemir® comprising l_ysB29 (Nε-tetradecanoyl) des(B30) human insulin (cf. insulin detemir). Another example is NεB29-(Nα-(w-carboxypentadecanoyl)-L-Y-glutamyl) des (B30) human insulin (cf. insulin degludec).
In a further embodiment, long-acting insulin is one that comprises positively charged amino acids such as Arg attached to the C-terminal end of the B chain. A commercial product is Lantus® comprising human insulin Gly^21, ArgB31, ArgB32 ( cf. insulin glargine).
Insulin glargine (sold as LANTUS® by Sanofi-Aventis) is approved and sold for subcutaneous administration once daily. Insulin glargine provides relatively constant glucose-lowering activity over a 24-hour period and can be given at any time during the day as long as it is given at the same time each day.
Insulin detemir (sold as LEVEMIR® by Novo Nordisk) is approved and sold for subcutaneous administration twice a day or once a day, preferably with an evening meal or at bedtime.
Insulin degludec (NN1250) is a soluble, ultra-long acting insulin with a duration of action of more than 24 hours. Degludec has a very flat, predictable and smooth action profile. It is intended for subcutaneous administration once a day or less (eg, three times a week).
Furthermore, additional examples of the long acting insulin may include, without being limited to, - insulin lispro PEGylated with high molecular weight poly(ethylene glycol) derivatives mainly as described in WO 2009/152128 (the description of which is incorporated in this application), such as, for example, PEGylated insulin lispro compound of formula P-[(A)-(B)], or a pharmaceutically acceptable salt thereof, wherein A is the A chain of insulin lispro, B is the B chain of insulin lispro, and P is a PEG having a molecular weight in the range of approximately 17.5 kDa to approximately 40 kDa, and where A and B are properly interconnected and P is linked via a covalent bond. urethane lens to the epsilon-amino group of lysine at position 28 of B; - amidated insulin glargine especially in the form of human insulin Gly^1, ArgB31, ArgB32-NH2 (insulin glargine amide, ie the C-terminal of the B chain of insulin glargine is amidated) as described in WO 2008/006496 or WO 2008/006496 (the disclosures of which are incorporated in this application); - l_ysB29 human insulin (Nε-litocholyl-Y-Glu)des(B30) or NεB29-α)-carboxypentadecanoyl-y-amino-butanoyl des (B30) human insulin; or - amidated insulin analogues as described in WO 2009/087082 (the description of which is incorporated in this application), especially one selected from claim 14, or in WO 2009/087081 (the description of which is incorporated in this application), especially a selected from claim 16.
Long-acting insulin analogues are typically given as basic antidiabetic therapy to patients with type 2 diabetes, type 1 diabetes, or adult-onset latent autoimmune diabetes (LADA) to control blood sugar when no food intake occurs. As mentioned above, this type of insulin provides a continuous level of insulin activity for up to 36 hours. Long-acting insulin operates at full strength after approximately 8 to 12 hours. Because of their advantages, it is believed that treatment with these insulin analogues may lead to a beneficial effect, for example, less hypoglycemia, less weight gain or better metabolic control which possibly results in fewer diabetic later complications such as problems with eyes, kidneys or feet and myocardial infarction, stroke or death. DPP-4 inhibitors are a diverse group of antidiabetics, which however also work via insulin-increasing mechanisms and limited in β-cells still functioning to trigger endogenous insulin secretion. DPP-4 inhibitors reduce glucagon levels and reduce postprandial glucose spikes during food intake through increased GLP-1 and subsequent mechanisms. The combination of these two principles is indeed a favorable approach in controlling effective fasting and postprandial glucose levels. Also, by the complementary modes of action improved glucose tolerance, improved metabolic (glycemic) status and/or sustainable efficacy can be achieved and/or maintained for a longer time. Linagliptin is the only DPP-4 inhibitor that demonstrates a superior pharmacokinetic profile (eg, half-life up to 72 h, reversible stoichiometric binding to DPP-4 protein) to potentially be administered once daily, every other day, or even longer. In addition, several DPP-4 substrates (eg, SDF-1, BNP) have been shown to have increased half-lives and actions after inhibition of DPP-4 and thus potentially be of additional benefit to cardiovascular outcome. Combining linagliptin with insulin according to this invention in this way is considered to further reduce late-stage macrovascular complications.
In monitoring the treatment of diabetes mellitus, the value of HbA1c, a product of a non-enzymatic glycation of the B chain of hemoglobin, is of exceptional importance. As its formation depends essentially on the blood sugar level and the lifespan of erythrocytes, HbA1c in terms of a "blood sugar memory" reflects the average blood sugar level of the preceding 4-12 weeks. Diabetic patients whose HbA1c level was well controlled for a long time by more intensive diabetes treatment (ie, <6.5% of total hemoglobin in the sample) are significantly better protected from diabetic microangiopathy. Available diabetes treatments can provide the diabetic with an average improvement in their HbA1c level on the order of 1.0 - 1.5%. This reduction in the level of HbA1C is not sufficient in all diabetics to bring them into the desired target range of <7.0%, preferably <6.5% and most preferably HbA1c <6%.
Within the meaning of this invention, inadequate or insufficient glycemic control means in particular a condition in which patients show HbA1c values above 6.5%, in particular above 7.0%, even more preferably above 7.5%, especially above 8%. A modality of patients with inadequate or poor glycemic control includes, but is not limited to, patients having an HbA1c value of 7.5 to 10% (or, in another modality, 7.5 to 11%). A special submodality of inadequately controlled patients refers to patients with poor glycemic control including, but not limited to, patients who have an HbA1c value >9%.
Within glycemic control, in addition to improving the level of HbA1c, other therapeutic goals recommended for patients with type 2 diabetes mellitus are improving fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) levels to normal or close to from normal while possible. Recommended target ranges for preprandial (fasting) plasma glucose are 70-130 mg/dL (or 90-130 mg/dL) or <110 mg/dL, and two-hour postprandial plasma glucose are <180 mg /dL or <140 mg/dL.
In one embodiment, diabetes patients within the meaning of this invention may include patients who have not previously been treated with an antidiabetic drug (drug-pure patients). Thus, in one embodiment, the therapies described in this application can be used on pure patients. In another embodiment, diabetes patients within the meaning of this invention may include patients with advanced stage or late type 2 diabetes mellitus (including patients with insufficiency of conventional antidiabetic therapy), such as, for example, patients with the inadequate glycemic control in one, two or more conventional oral and/or non-oral antidiabetic drugs as defined in this application, such as, for example, patients with poor glycemic control despite (mono-)therapy with metformin, a thiazolidinedione (particularly pioglitazone), a sulfonylurea, a glinide, GLP-1 or GLP-1 analogue, insulin or insulin analogue, or an α-glucosidase inhibitor, or despite dual metformin/sulfonylurea combination therapy, met - formin/thiazolidinedione (particularly pioglitazone), sulfonylurea/a-glucosidase inhibitor, pioglitazone/sulfonylurea, metformin/insulin, pioglitazone/insulin or sulfonylurea/insulin. Thus, in one embodiment, the therapies described in this application can be used in patients experienced with therapy, for example, with conventional oral and/or non-oral single or dual or triple combination antidiabetic medication as mentioned in this application.
A further embodiment of diabetic patients within the meaning of this invention relates to patients ineligible for metformin therapy including - patients for whom metformin therapy is contraindicated, for example, patients having one or more contraindications against metformin therapy. according to the marker, such as, for example, patients with at least one contraindication selected from: renal disease, renal failure or renal dysfunction (eg, as specified by locally approved metformin product information), dehydration, congestive heart failure unstable or acute, acute or chronic metabolic acidosis, and hereditary galactose intolerance; and - patients suffering from one or more intolerable side effects attributed to metformin, particularly gastrointestinal side effects associated with metformin, such as, for example, patients suffering from at least one gastrointestinal side effect selected from: nausea, vomiting, diarrhea, gas intestinal disorders, and severe abdominal discomfort.
An additional embodiment of diabetes patients who may be amenable to the therapies of this invention may include, but are not limited to, those diabetes patients for whom normal metformin therapy is not appropriate, such as, for example, those diabetes patients who need it. reduced dose metformin therapy due to reduced tolerability, intolerability or contraindication to metformin or due to (mildly) impaired/reduced renal function (including elderly patients, such as eg â 60-65 years).
A further embodiment of diabetic patients within the meaning of this invention relates to patients having renal disease, renal dysfunction, or impaired or impaired renal function (including mild, moderate, and severe renal failure), for example, as suggested by creatinine levels Elevated serum creatinine levels (eg, serum creatinine levels above the upper limit of normal for your age, eg, £130 - 150 μmol/l, or £1.5 mg/dl (> 136 μmol/l) in men and > 1.4 mg/dl (£ 124 μmol/l) in women) or abnormal creatinine clearance (eg, glomerular filtration rate (GFR) <30-60 ml/min).
In this context, for a more detailed example, mild renal failure can be, for example, suggested by a creatinine clearance of 50-80 ml/min (approximately corresponding to serum creatine levels of 1.7 mg/dL in men and £1 .5 mg/dL in women); moderate renal impairment may be, for example, suggested by a creatinine clearance of 30-50 ml/min (approximately corresponding to serum creatinine levels of > 1.7 to £ 3.0 mg/dL in men and > 1.5 a < 2.5 mg/dL in women); and severe renal failure may be, for example, suggested by a creatinine clearance of <30 ml/min (approximately corresponding to serum creatinine levels of > 3.0 mg/dL in men and > 2.5 mg/dL in women) . Patients with end-stage kidney disease require dialysis (eg, hemodialysis or peritoneal dialysis).
For another more detailed example, patients with kidney disease, kidney dysfunction, or kidney failure include patients with chronic kidney failure or impairment, which can be stratified according to glomerular filtration rate (GFR, ml/min/1.73m2) in 5 disease stages: stage 1 characterized by normal GFR £90 plus persistent albuminuria or more known structural or inherited kidney disease; stage 2 characterized by mild reduction in GFR (GFR 60-89) description of mild renal failure; stage 3 characterized by moderate dGFR reduction (GFR 30-59) describing moderate renal failure; stage 4 characterized by severe reduction in GFR (GFR 15-29) describing severe renal failure; and end stage 5 characterized by need for dialysis or GFR <15 describing established renal failure (end-stage renal disease, ESRD).
A further embodiment of diabetic patients within the meaning of this invention relates to patients with type 2 diabetes with or at risk of developing renal complications such as diabetic nephropathy (including chronic and progressive renal failure, albuminuria, proteinuria, body fluid retention (edema) and/or hypertension).
In a further embodiment, patients within the present invention may include patients of type 1 diabetes, LADA or particularly type 2 diabetes, with or without obesity or overweight.
Within the limits of the present invention it has now been found that certain DPP-4 inhibitors as defined in this application as well as pharmaceutical combinations, compositions or combined uses according to this invention of these DPP-4 inhibitors and long acting insulin (such as, by example, insulin glargine, insulin detemir or insulin degludec) as defined in this application have properties, which make them suitable for the purposes of this invention and/or to fulfill one or more of the above needs.
The present invention thus relates to a combination comprising a certain DPP-4 inhibitor (particularly B11356) and a long-acting insulin (such as, for example, insulin glargine, insulin detemir or insulin degludec), each. as defined in this application, particularly for simultaneous, separate or sequential use in the therapies described in this application.
The present invention further relates to a certain DPP-4 inhibitor (particularly BI 1356) in combination with a long-acting insulin (such as, for example, insulin glargine, insulin detemir or insulin degludec), each as defined herein. application, for use in the therapies described in this application.
The present invention further relates to a method for treating and/or preventing metabolic diseases, especially type 2 diabetes mellitus and/or conditions related thereto (e.g. diabetic complications) comprising combined administration (e.g. simultaneous, separate or sequential) of an effective amount of a long-acting insulin (such as, for example, insulin glargine, insulin detemir or insulin degludec) as defined in this application and an effective amount of a DPP-4 inhibitor such as defined in this application to the patient (particularly human patient) in need thereof, such as, for example, a patient as described in this application.
The present invention further relates to at least one of the following methods: preventing, reducing the progression, delaying or treating a metabolic disorder or disease, such as, for example, diabetes mellitus type 1, diabetes mellitus type 2, impaired glucose tolerance (IGT), impaired fasting blood glucose (IFG), hyperglycemia, postprandial hyperglycemia, postabsorptive hyperglycemia, overweight, obesity, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hypertension, atherosclerosis, endothelial dysfunction, osteoporosis, chronic systemic inflammation, non-alcoholic fatty liver disease (NAFLD), retinopathy, neuropathy, nephropathy, polycystic ovary syndrome and/or metabolic syndrome; - improvement and/or maintenance of glycemic control and/or reduction of fasting plasma glucose, postprandial plasma glucose, postabsorptive plasma glucose and/or glycosylated hemoglobin HbA1c; - prevention, reduction of speed, delay or reversal of the progression of prediabetes, impaired glucose tolerance (IGT), impaired fasting blood glucose (IFG), insulin resistance and/or metabolic syndrome for diabetes mellitus type 2; - prevention, reduction of risk, reduction of speed of progression, delay or treatment of complications of diabetes mellitus such as micro- and macrovascular diseases, such as nephropathy, micro- or macroalbuminuria, proteinuria, retinopathy, cataracts, neuropathy, impairment of learning or memory, neurogenerative or cognitive disorders, cardio- or cerebrovascular diseases, tissue ischemia, diabetic foot or ulcus, atherosclerosis, hypertension, endothelial dysfunction, myocardial infarction, acute coronary syndrome, unstable angina pectoris, stable angina pectoris, peripheral arterial occlusive disease, cardiomyopathy, heart failure, heart rhythm disturbances, vascular restenosis, and/or stroke; - reduction in body weight and/or body fat and/or liver fat and/or intramyocellular fat or preventing an increase in body weight and/or body fat and/or liver fat and/or intramyocellular fat or facilitating a reduction in body weight and/or body fat and/or liver fat and/or intramyocellular fat; - prevention, reduction of speed, delay or treatment of pancreatic beta cell degeneration and/or decline of pancreatic beta cell functionality and/or for improvement, conservation and/or restoration of pancreatic beta cell functionality and/or stimulation and /or restoration or protection of pancreatic insulin secretion functionality; - prevention, reduction of speed, delay or treatment of non-alcoholic fatty liver disease (NAFLD) including hepatic steatosis, non-alcoholic steatohepatitis (NASH) and/or liver fibrosis (such as, for example, prevention, reduction of speed of progression, delay, attenuation, treatment or reversal of hepatic steatosis, inflammation (hepatic) and/or an abnormal accumulation of hepatic fat); - prevention, slowing of progression, delay or treatment of type 2 diabetes with failure to conventional antidiabetic therapy alone or in combination; - carrying out a dose reduction of conventional antidiabetic medication necessary for the proper therapeutic effect; - reduced risk of adverse effects associated with conventional antidiabetic medication (eg hypoglycaemia or weight gain); and/or - maintenance and/or improvement of insulin sensitivity and/or to treat or prevent hyperinsulinemia and/or insulin resistance; in a patient in need thereof (such as, for example, a patient as described in this application), said method comprising combined (e.g., simultaneous, separate or sequential) administration of a DPP-inhibitor. 4 as defined in this order and a long acting insulin as defined in this order.
The present invention further relates to a certain DPP-4 inhibitor (particularly BI 1356) as defined in this application for subcutaneous or transdermal use in the therapies described in this application.
The present invention further relates to a method for treating and/or preventing metabolic diseases, especially type 2 diabetes mellitus and/or conditions related thereto (e.g. diabetic complications) comprising administering an effective amount of an inhibitor of DPP-4 as defined in this application, optionally in combination with one or more therapeutic agents as described in this application, to the patient (particularly human patient) in need thereof (such as, for example, a patient as described in this application), wherein administration of the DPP-4 inhibitor, and optionally one or more therapeutic agents, is parenterally, such as, for example, subcutaneously or transdermally.
The present invention further relates to the use of a DPP-4 inhibitor as defined in this application for the production of a pharmaceutical composition for subcutaneous use in the treatment and/or prevention of a metabolic disease, disorder or condition such as, for example, described in this application, especially type 2 diabetes mellitus and/or conditions related thereto (e.g. diabetic complications).
The present invention further relates to at least one of the following methods: preventing, reducing the progression, delaying or treating a metabolic disorder or disease such as, for example, diabetes mellitus type 1, diabetes mellitus type 2, impaired glucose tolerance (IGT), impaired fasting blood glucose (IFG), hyperglycemia, postprandial hyperglycemia, postabsorptive hyperglycemia, overweight, obesity, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hypertension, atherosclerosis, endothelial dysfunction, osteoporosis, chronic systemic inflammation, non-alcoholic fatty liver disease (NAFLD), retinopathy, neuropathy, nephropathy, polycystic ovary syndrome and/or metabolic syndrome; - improvement and/or maintenance of glycemic control and/or reduction of fasting plasma glucose, postprandial plasma glucose, postabsorptive plasma glucose and/or glycosylated hemoglobin HbA1c; - prevention, reduction of speed, delay or reversal of the progression of prediabetes, impaired glucose tolerance (IGT), impaired fasting blood glucose (IFG), insulin resistance and/or metabolic syndrome for diabetes mellitus type 2; - prevention, reduction of risk, reduction of speed of progression, delay or treatment of complications of diabetes mellitus such as micro- and macrovascular diseases, such as nephropathy, micro- or macroalbuminuria, proteinuria, retinopathy, cataracts, neuropathy, impairment of learning or memory, neurogenerative or cognitive disorders, cardio- or cerebrovascular diseases, tissue ischemia, diabetic foot or ulcus, atherosclerosis, hypertension, endothelial dysfunction, myocardial infarction, acute coronary syndrome, unstable angina pectoris, stable angina pectoris, peripheral arterial occlusive disease, cardiomyopathy, heart failure, heart rhythm disturbances, vascular restenosis, and/or stroke; - reduction of body weight and/or body fat and/or liver fat and/or intramyocellular fat or preventing an increase in body weight and/or body fat and/or liver fat and/or intramyocellular fat or facilitating a reduction of body weight and/or body fat and/or liver fat and/or intramyocellular fat; - prevention, reduction of speed, delay or treatment of pancreatic beta cell degeneration and/or decline of pancreatic beta cell functionality and/or for improvement, conservation and/or restoration of pancreatic beta cell functionality and/or stimulation and/or restoration or protection of the functionality of pancreatic insulin secretion; - prevention, reduction of speed, retardation or treatment of non-alcoholic fatty liver disease (NAFLD) including hepatic steatosis, non-alcoholic steatohepatitis (NASH) and/or liver fibrosis (such as, for example, prevention, reduction of speed the progression, delay, attenuation, treatment or reversal of hepatic steatosis, inflammation (hepatic) and/or an abnormal accumulation of hepatic fat); - prevention, slowing of progression, delay or treatment of type 2 diabetes with failure to conventional antidiabetic therapy alone or in combination; - carrying out a dose reduction of conventional antidiabetic medication necessary for the proper therapeutic effect; - reduced risk of adverse effects associated with conventional antidiabetic medication (eg hypoglycaemia or weight gain); and/or - maintenance and/or improvement of insulin sensitivity and/or to treat or prevent hyperinsulinemia and/or insulin resistance; in a patient in need thereof (such as, for example, a patient as described in this application), said method comprising the parenteral administration, preferably subcutaneous or transdermal, of a DPP-4 inhibitor as defined in this application, optionally in combination with one or more therapeutic agents as described in this application.
Furthermore, the present invention relates to the combination according to this invention comprising a DPP-4 inhibitor as defined in this application and a long-acting insulin as defined in this application for parenteral administration, particularly subcutaneous or transdermal, of one or both of the active components to the patient in need thereof.
Furthermore, the present invention relates to a pharmaceutical composition according to this invention comprising - a DPP-4 inhibitor as defined in this application, a long-acting insulin as defined in this application, and optionally one or more carriers and /or pharmaceutically acceptable diluents, said composition being for subcutaneous administration to the patient in need thereof, for example, by injection.
Furthermore, the present invention relates to the combination according to this invention comprising a DPP-4 inhibitor as defined in this application and a long-acting insulin as defined in this application for use in treatment and/or prevention (including slowing down of progression or delaying onset) of metabolic diseases as defined in this application, particularly diabetes (especially type 2 diabetes or conditions related thereto, including diabetic complications), optionally in combination with a or more therapeutic agents as described in this application.
Furthermore, the present invention relates to the use of a combination according to this invention comprising a DPP-4 inhibitor as defined in this application and a long-acting insulin as defined in this application for the production of a medicament for use in a therapeutic method as described above or below.
Furthermore, the present invention relates to a combination according to this invention comprising a DPP-4 inhibitor as defined in this application and a long-acting insulin as defined in this application for use in a therapeutic method as described above. or below.
Furthermore, the present invention relates to a method of treating and/or preventing (including slowing the progression or delaying the onset) of a metabolic disease, particularly diabetes (especially type 2 diabetes) or related conditions. thereto, including diabetic complications, comprising administering to the patient in need thereof (such as, for example, a patient as described in this application) of a combination according to this invention comprising a DPP-4 inhibitor as defined in this application. and a long-acting insulin as defined in this application.
Furthermore, the present invention relates to a DPP-4 inhibitor as defined in this application for use in a method as described above or below, said method comprising administering the DPP-4 inhibitor, optionally combined with one or more active substances (for example, which may be selected from those mentioned in this application, such as, for example, metformin or pioglitazone), in combination (for example, separately, simultaneously or sequentially) with a long-acting insulin as defined in this patient application.
Furthermore, the present invention relates to a long-acting insulin as defined in this application for use in a method as described above or below, said method comprising administering the long-acting insulin, optionally combined with one or more substances. active (for example, which may be selected from those mentioned in this application, such as, for example, metformin or pioglitazone), in combination (for example, separately, simultaneously or sequentially) with a DPP-4 inhibitor as defined in this request to the patient.
Furthermore, the present invention relates to the use of a DPP-4 inhibitor as defined in this application for the production of a medicament for use in combination with a long-acting insulin as defined in this application for treatment and/or prevention (including reduction in the rate of progression or delay in onset) of metabolic diseases, particularly diabetes (especially type 2 diabetes) and related conditions, including diabetic complications.
Furthermore, the present invention relates to the use of a long-acting insulin as defined in this application for the production of a medicament for use in combination with a DPP-4 inhibitor as defined in this application for treatment and/or prevention (including slowing of progression or delaying onset) of metabolic diseases, particularly diabetes (especially type 2 diabetes) or related conditions, including diabetic complications.
Furthermore, the present invention relates to the use of a DPP-4 inhibitor as defined in this application, optionally in combination with one or more active substances (such as, for example, metformin or pio-glitazone), for the production of a medicine for use in combination with a long-acting insulin as defined in this application for the treatment and/or prevention (including slowing of progression or delaying onset) of metabolic diseases, particularly diabetes (especially type 2 diabetes) or conditions related to it, including diabetic complications.
Furthermore, the present invention relates to a DPP-4 inhibitor as defined in this application for use in a combination treatment according to the invention in a patient in need thereof (such as, for example, a patient such as described in this application).
Furthermore, the present invention relates to a long-acting insulin as defined in this application for use in a combination treatment according to the invention in a patient in need thereof (such as, for example, a patient as described. in this application).
Furthermore, the present invention relates to a DPP-4 inhibitor as defined in this application, optionally in combination with one or more active substances (such as, for example, metformin or pioglitazone), for use in a treatment. combination according to the invention in a patient in need thereof.
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application for use in a method as described above or below, said method comprising administering the DPP-4 inhibitor, optionally in combination with one or more active substances (for example, which may be selected from those mentioned in this application, such as, for example, metformin or pioglitazone), to the patient.
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application for use in a method of preventing, reducing risk, slowing progression, delaying or treating weight gain associated with an insulin therapy. long-acting as defined in this application, preferably said method comprising administering the DPP-4 inhibitor and long-acting insulin to the patient (e.g. patient with type 1 diabetes, LADA or particularly type 2 diabetes, with or without obesity or overweight).
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application for use in a method of preventing, reducing risk, slowing progression, delaying or treating an increase in body weight and/or fat. body and/or liver fat and/or intramyocellular fat that can be associated with therapy with a long acting insulin as defined in this application, preferably said method comprising administering the DPP-4 inhibitor and long acting insulin to the patient (for example , patient with type 1 diabetes, LADA or particularly type 2 diabetes, with or without obesity or overweight).
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application for use in a composition method of improving body fat and/or obesity parameters that may be associated with long-acting insulin therapy such as defined in this application, preferably said method comprising administering the DPP-4 inhibitor and long-acting insulin to the patient (e.g. patient with type 1 diabetes, LADA or particularly type 2 diabetes, with or without obesity or overweight).
Furthermore, the invention relates to a DPP-4 inhibitor and a long-acting insulin each as defined in this application for use in a method of improving diabetic phenotype, improving glycemic and/or metabolic control, improving profile of glucose (blood) (eg, improved control of fasting and/or postprandial blood glucose levels) and/or improved glucagon suppression (eg, long-term and/or during chronic treatment), preferably said method comprising administering the DPP-4 inhibitor and long-acting insulin to the patient (e.g. patient with type 1 diabetes, LADA or particularly type 2 diabetes, with or without obesity or overweight).
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application for use in a method of saving or reducing the amount of long-acting insulin as defined in this application necessary for effective therapeutic treatment and/or safe, said method comprising administering the DPP-4 inhibitor and long-acting insulin to the patient (for example, patient with type 1 diabetes, LADA or, particularly, type 2 diabetes, with or without obesity or overweight) .
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application for use in a therapeutic or preventive method as described in this application, said use comprising adding the DPP-4 inhibitor to long acting insulin as defined. in this application alone or in combination with one or more antidiabetic drugs (eg, selected from metformin, pioglitazone and a sulphonylurea), for example, to improve glycemic control in a patient (eg, patient with diabetes type 1, LADA or particularly type 2 diabetes, with or without obesity or overweight) which may be inadequately controlled with insulin alone or in combination with one or more antidiabetic drugs (eg selected from metformin, pioglitazone and a sulfonylurea).
Furthermore, the invention relates to a DPP-4 inhibitor and a long-acting insulin each as defined in this application for use in a therapeutic or preventive method as described in this application, said use comprising addition of the DPP-inhibitor. 4 and from long-acting insulin to one or more antidiabetic drugs (eg, selected from metformin, pioglitazone and a sulphonylurea), for example, to improve glycemic control in a patient (eg, patient with type 1 diabetes, LADA or particularly type 2 diabetes, with or without obesity or overweight) which may be inadequately controlled with one or more antidiabetic drugs (eg, selected from metformin, pioglitazone and a sulphonylurea).
Furthermore, the invention relates to a long-acting insulin as defined in this application for use in a therapeutic or preventive method as described in this application, said use comprising adding long-acting insulin to a DPP-4 inhibitor. as defined in this application alone or in combination with one or more antidiabetic drugs (eg selected from metformin, pioglitazone and a sulfonylurea), eg to improve glycemic control in a patient (eg patient with type 1 diabetes, LADA, or particularly type 2 diabetes, with or without obesity or overweight) which may be inadequately controlled with a DPP-4 inhibitor alone or in combination with one or more antidiabetic drugs (eg, selected from of met-formin, pioglitazone and a sulfonylurea).
Furthermore, the invention relates to a combination or composition comprising a DPP-4 inhibitor and a long acting insulin each as defined in this application for use in treatment and/or prevention as described in this application, optionally in combination with one or more therapeutic agents.
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application with or without metformin and/or pioglitazone in combination with a long acting insulin as defined in this application for therapeutic or preventive use as described in this application. .
Furthermore, the invention relates to a DPP-4 inhibitor as defined in this application in combination with a long acting insulin as defined in this application, with or without metformin, for use in a method of therapy or prophylaxis as described. in this application.
Other aspects of the present invention will be apparent to the skilled artisan from foregoing and subsequent observations (including the examples and claims).
Aspects of the present invention, in particular pharmaceutical compounds, compositions, combinations, methods and uses, relate to long acting DPP-4 and/or insulin inhibitors as defined above and below.
A DPP-4 inhibitor within the meaning of the present invention includes, without being limited to, any of those DPP-4 inhibitors mentioned above and below, preferably orally- and/or subcutaneously active DPP-4 inhibitors.
One embodiment of this invention relates to a DPP-4 inhibitor for use in the treatment and/or prevention of metabolic diseases (particularly type 2 diabetes mellitus) in patients with type 2 diabetes, said patients still suffering from renal disease, renal dysfunction or renal failure, particularly characterized in that said DPP-4 inhibitor is administered to said patients at the same dose levels as to patients with normal renal function, thus for example, said inhibitor of DPP-4 does not require downward dosage adjustment for impaired renal function.
For example, a DPP-4 inhibitor according to this invention (especially one that can be adjusted for patients with impaired renal function) may be an oral DPP-4 inhibitor, which and whose active metabolites preferably have a relatively broad therapeutic window (eg approximately >100-fold) and/or especially ie mainly eliminated via hepatic metabolism or biliary excretion (preferably without adding extra burden to the kidney).
In more detailed example, a DPP-4 inhibitor according to this invention (especially one that can be adjusted for patients with impaired renal function) may be an orally administered DPP-4 inhibitor, which has a relatively wide therapeutic window (by example, >100-fold) (preferably a safety profile comparable to placebo) and/or that it fulfills one or more of the following pharmacokinetic properties (preferably at its therapeutic oral dose levels): - The DPP-4 inhibitor is substantially or primarily excreted via the liver (eg, >80% or even >90% of the administered oral dose), and/or for which renal excretion does not represent a substantial or only minor route of elimination (eg, <10% , preferably <7%, of the administered oral dose measured, for example, by following elimination of an oral dose substance with radiolabelled carbon (14C)); - DPP-4 inhibitor is excreted mainly unchanged as a parent drug (eg with an average of >70%, or >80%, or preferably 90% of the radioactivity excreted in urine and faeces after oral dosing of the substance with radiolabelled carbon (14C)), and/or which is eliminated to an insubstantial or only a minor extent through metabolism (eg, <30%, or <20%, or, preferably, 10%); - The (major) metabolite(s) of the DPP-4 inhibitor is pharmacologically inactive. As, for example, the major metabolite does not bind to the target enzyme of DPP-4 and, optionally, is rapidly cleared compared to the parent compound (eg, with a terminal half-life of the metabolite of £20 h , or, preferably, < approximately 16 h, such as, for example, 15.9 h).
In one embodiment, the (major) plasma metabolite (which may be pharmacologically inactive) of a DPP-4 inhibitor having a 3-amino-piperidin-1-yl substituent is a derivative where the amino group of the 3-amino- portion piperidin-1-yl is substituted by a hydroxyl group to form the 3-hydroxy-piperidin-1-yl moiety (for example, the 3-(S)-hydroxy-piperidin-1-yl moiety, which is formed by inversion of the chiral center configuration).
Additional properties of a DPP-4 inhibitor according to this invention may be one or more of the following: rapid steady-state attainment (eg achieving constant steady-state plasma levels (>90% constant steady-state plasma concentration) ) between the second and fifth day of treatment with therapeutic oral dose levels), little accumulation (eg with an average accumulation ratio RA,AUC - 1.4 with therapeutic oral dose levels), and/or conservation of a long-lasting effect on DPP-4 inhibition, preferably when used once daily (eg, with nearly complete (>90%) DPP-4 inhibition at therapeutic oral dose levels, >80% inhibition across of an interval of 24 h after ingestion of once daily oral therapeutic dose of drug), significant reduction within 2 h of postprandial blood glucose excursions by >80% (already on the first day of therapy) at therapeutic dose levels , and cumulative amount of parent compound i unaltered excreted in the urine on the first day being below 1% of the administered dose and increasing to no more than approximately 3-6% in the permanent state.
Thus, for example, a DPP-4 inhibitor according to this invention can be characterized in that said DPP-4 inhibitor has a primarily non-renal excretion pathway, i.e., said DPP-4 inhibitor is excreted. to an insubstantial extent or only to a minor extent (eg <10%, preferably <7%, eg approximately 5%, of the administered oral dose, preferably of the oral therapeutic dose) via the kidney (measured, for example, by following elimination of an oral dose substance with radiolabelled carbon (14C).
Furthermore, a DPP-4 inhibitor according to this invention can be characterized in that said DPP-4 inhibitor is excreted substantially or mainly via the liver or feces (measured, for example, by the following elimination of a carbon radiolabeled (14C) oral dose substance).
Furthermore, a DPP-4 inhibitor according to this invention can be characterized in that said DPP-4 inhibitor is excreted mostly unchanged as a parent drug (e.g., with an average of >70%, or >80 %, or preferably 90% of the radioactivity excreted in urine and faeces after oral dosing of the substance with radiolabelled carbon (14C)), said DPP-4 inhibitor is eliminated to a non-substantial extent or only to a lesser extent via metabolism, and/or the major metabolite of said DPP-4 inhibitor is pharmacologically inactive or has a relatively wide therapeutic window.
Furthermore, a DPP-4 inhibitor according to this invention can be characterized in that said DPP-4 inhibitor does not significantly impair glomerular and/or tubular function of type 2 diabetes patient with chronic renal failure (by example, mild, moderate or severe renal failure or end-stage renal disease), and/or said trough levels of the DPP-4 inhibitor in the blood plasma of type 2 diabetes patients with mild or moderate renal failure are comparable with levels in patients with normal renal function, and/or said DPP-4 inhibitor do not require dose adjustment in type 2 diabetes patients with impaired renal function (eg mild, moderate or severe renal failure or renal disease in end stage, preferably despite the stage of renal failure).
Furthermore, a DPP-4 inhibitor according to this invention can be characterized in that said DPP-4 inhibitor provides its minimally effective dose at that dose which results in >50% inhibition of DPP-4 activity in the trough (24 h after the last dose) in >80% of patients, and/or said DPP-4 inhibitor provides its fully therapeutic dose at that dose that results in >80% inhibition of trough DPP-4 activity (24 h after the last dose) in >80% of patients.
Furthermore, a DPP-4 inhibitor according to this invention can be characterized in that it is suitable for use in patients with type 2 diabetes who are diagnosed with renal failure and/or who are at risk of developing renal complications, for example , patients with or at risk of diabetic nephropathy (including chronic and progressive renal failure, albuminuria, proteinuria, body fluid retention (edema) and/or hypertension).
In a first embodiment (modality A), a DPP-4 inhibitor in the context of the present invention is any DPP-4 inhibitor of formula (I)
or formula (II)
or formula (III)
or formula (IV)
wherein R1 denotes ([1,5]naphthyridin-2-yl)methyl, (quinazolin-2-yl)methyl, (quinoxalin-6-yl)methyl, (4-methyl-quinazolin-2-yl)methyl , 2-cyano-benzyl, (3-cyano-quinolin-2-yl)methyl, (3-cyano-pyridin-2-yl)methyl, (4-methyl-pyrimidin-2-yl)methyl, or (4, 6-dimethyl-pyrimidin-2-yl)methyl and R2 denotes 3-(R)-amino-piperidin-1-yl, (2-amino-2-methyl-propyl)-methylamino or (2-(S)-amino -propyl)-methylamino, or its pharmaceutically acceptable salt.
In a second embodiment (modality B), a DPP-4 inhibitor in the context of the present invention is a DPP-4 inhibitor selected from the group consisting of sitagliptin, vildagliptin, saxagliptin, alogliptin, gemigliptin, (2S)-1- {[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile, (2S)-1-{[1,1,-Dimethyl-3-( 4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile, (S)-1-((2S,3S,11bS)-2-Amino-9,10- dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one, (3,3-Difluoropyrrolidin- 1-yl)-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, (1((3S,4S)-4-amino -1-(4-(3,3-difluoropyrrolidin-1-yl)-1,3,5-triazin-2-yl)pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one, (2S, 4S)-1-{2-[(3S,1R)-3-(1h-1,2,4-triazol-1-ylmethyl)cyclopentylamino]-acetyl}-4-fluoropyrrolidine-2-carbonitrile, (R )-2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4-fluoro ro-benzonitrile, 5-{(S)-2-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-propyl}-5-(acid bis-dimethylamide) 1H-tetrazol-5-yl)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-2,8-dicarboxylic, 3-{(2S,4S)-4-[4- (3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine, [(2R)-1-{[(3R)-pyrrolidin- acid 3-ylamino]acetyl}pyrrolidin-2-yl]boronic, (2S,4S)-1-[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine- 2-carbonitrile, 2-({6-[(3R)-3-amino-3-methylpiperidin-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetra- hydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl}methyl)-4-fluorobenzonitrile, 6-[(3R)-3-amino-piperidin-1-yl]-5-(2-chloro- 5-fluoro-benzyl)-1,3-dimethyl-1,5-dihydro-pyrrole[3,2-d]pyrimidine-2,4-dione, and {2-[(2-cyanopyrrolidin-1-yl) (S)-2-methylpyrazol[1,5-a]pyrimidine-6-carboxylic acid )-2-oxoethylamino]-2-methylpropyl}amide, or pharmaceutically acceptable salt thereof.
As for the first modality (modality A), the inhibitors of
Preferred DPP-4 are all or any of the following compounds and their pharmaceutically acceptable salts: 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)- 8-(3-(R)-amino-piperidin-1-yl)-xanthine (compare WO 2004/018468, example 2 (142)):
1-[([1,5]naphthyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((/)-3-amino- piperid i n-1 - yl)-xanthine (compare to WO 2004/018468, example 2 (252)):
1-[(Quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((/)-3-amino-piperidin-1-yl)- xanthine (compare WO 2004/018468, example 2 (80)):
2-((R)-3-Amino-piperidin-1-yl)-3-(but-2-ynyl)-5-(4-methyl-quinazolin-2-ylmethyl)-3,5-dihydro- imidazo[4,5-d]pyridazin-4-one (compare WO 2004/050658, 5 example 136):
1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(2-amino-2-methyl-propyl)-methylamino] -xanthine (compare to WO 2006/029769, example 2 (1)):
1-[(3-Cyano-quinolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((/ )-3-amino-10 piperidin-1- il)-xanthine (compare WO 2005/085246, example 1(30)):
1-(2-Cyano-benzyl)-3-methyl-7-(2-butyn-1-yl)-8-((/ )-3-amino-piperidin-1-yl)-xanthine (compare with WO 2005/085246, example 1(39)):
1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(S)-(2-amino-propyl)-methylamino]- xanthine (compare WO 2006/029769, example 2 (4)):
5 1-[(3-Cyano-pyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((/ )-3-amino-piperidin-1- il)-xanthine (compare WO 2005/085246, example 1 (52)):
1-[(4-methyl-pyrimidin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((/ )-3-amino-piperidin-1-yl )-xanthine (compare WO 2005/085246, example 1 (81)):
1-[(4,6-Dimethyl-pyrimidin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-((/ )-3-amino-piperidin-1 -yl)-xanthine (compare WO 2005/085246, example 1 (82)):
1-[(Quinoxalin-6-yl)methyl]-3-methyl-7-(2-butyn-141)4^((/ )-3-amino-piperidin-1-yl)-xanthine (compare with WO 2005/085246, example 1 (83)):

These DPP-4 inhibitors are distinguished from structurally comparable DPP-4 inhibitors as they combine exceptional potency and a long-lasting effect with favorable pharmacological properties, receptor selectivity and a favorable side-effect profile, or bring about unexpected therapeutic advantages or improvements when combined with other pharmaceutical active substances. Its preparation is described in the aforementioned publications.
A most preferred DPP-4 inhibitor among the aforementioned DPP-4 inhibitors of embodiment A of this invention is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2- butyn-1-yl)-8-(3-(7')-amino-piperidin-1-yl)-xanthine, particularly the free base thereof (which is also known as linagliptin or B11356).
As additionally DPP-4 inhibitors, the following compounds can be mentioned: - Sitagliptin (MK-0431) having the structural formula A below is (3/ )-3-amino-1 -[3-(trifluoromethyl)-5 ,6,7,8-tetrahydro-5H-[1,2,4]triazol[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1- one, also called (2/ )-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazol[4,3-a]pyrazin-7(8Af )-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine,

In one embodiment, sitagliptin is in the form of its dihydrogen phosphate salt, ie, sitagliptin phosphate. In a further embodiment, sitagliptin phosphate is in the form of a crystalline anhydrate or monohydrate. One class of this modality refers to sitagliptin phosphate monohydrate. Sitagliptin free base and pharmaceutically acceptable salts thereof are described in US Patent No. 6.699,871 and Example 7 of WO 03/004498. Crystalline sitagliptin phosphate monohydrate is described in WO 2005/003135 and in WO 2007/050485.
For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents.
A tablet formulation of sitagliptin is commercially available under the trade name Januvia®. A tablet formulation of the sitagliptin/metformin combination is commercially available under the trade name Janumet®. - Vildagliptin (LAF-237) having the structural formula B below is (2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile, also called (S)-1 -[(3 -hydroxy-1-adamantyl)amino]acetyl-2-cyano-pyrrolidine,

Vildagliptin is specifically described in US Patent No. 6,166,063 and Example 1 of WO 00/34241. Specific salts of vildagliptin are described in WO 2007/019255. A crystalline form of vildagliptin as well as a tablet formulation of vildagliptin is described in WO 2006/078593. Vildagliptin can be formulated as described in WO 00/34241 or in WO 2005/067976. A modified release formulation of vildagliptin is described in WO 2006/135723.
For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents.
A tablet formulation of vildagliptin is expected to be commercially available under the trade name Galvus®. A tablet formulation for the vildagliptin/metformin combination is commercially available under the trade name Eucreas®. - Saxagliptin (BMS-477118) having the structural formula C below is (1S,3S,5S)-2-{(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl}-2-azabicyclo [3.1.0] hexane-3-carbonitrile, also called (S)-3-hydroxyadamantylglycine-Lc/s-4,5-methanoprolinenitrile,

Saxagliptin is specifically described in US Patent No. 6,395,767 and Example 60 of WO 01/68603.
In one embodiment, saxagliptin is in the form of its HCI salt or its monobenzoate salt as described in WO 2004/052850. In an additional modality, saxagliptin is in free base form. In a further embodiment, saxagliptin is in the monohydrate form of the free base as described in WO 2004/052850. Crystalline forms of the HCI salt and the free base of saxagliptin are described in WO 2008/131149. A process for preparing saxagliptin is also described in WO 2005/106011 and WO 2005/115982. Saxagliptin can be formulated into a tablet as described in WO 2005/117841.
For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. - Alogliptin (SYR-322) having the structural formula E below is 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-di- hydro-2H-pyrimidin-1-yl}methyl) benzonitrile

Alogliptin is specifically described in US 2005/261271, EP 1586571 and WO 2005/095381.
In one embodiment, alogliptin is in the form of its benzoate salt, its hydrochloride salt, or its tosylate salt each as described in WO 2007/035629. One class of this modality refers to alogliptin benzoate. Alogliptin benzoate polymorphs are described in WO 2007/035372. A process for preparing alogliptin is described in WO 2007/112368 and specifically in WO 2007/035629. Alogliptin (ie its benzoate salt) can be formulated into a tablet and administered as described in WO 2007/033266. A solid preparation of alogliptin/pioglitazone and its preparation and use are described in WO 2008/093882. A solid alogliptin/metformin preparation and its preparation and use are described in WO 2009/011451.
For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. (2S)-1 -{[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile or a pharmaceutically acceptable salt thereof, preferably mesylate, or ( 2S)-1-{[1,1,-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile or a pharmaceutically acceptable salt thereof :
These compounds and methods for their preparation are described in WO 03/037327.
The mesylate salt of the above compounds as well as crystalline polymorphs thereof are described in WO 2006/100181. The fumarate salt of the compounds cited below as well as crystalline polymorphs thereof are described in WO 2007/071576. These compounds can be formulated into a pharmaceutical composition as described in WO 2007/017423.
For details, for example, in a process for the production, formulation or use of these compounds or salts thereof, reference is thus made to these documents. (S)-1 -((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a ]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one (also called carmegliptin) or a pharmaceutically acceptable salt thereof:

This compound and methods for its preparation are described in WO 2005/000848. A process for preparing this compound (specifically its dihydrochloride salt) is also described in WO 2008/031749, WO 2008/031750 and WO 2008/055814. This compound can be formulated into a pharmaceutical composition as described in WO 2007/017423.
For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. - (3,3-Difluoropyrrolidin-1-yl)-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl) dirrolidin-2-ihmethanone (also called gosogliptin) or a pharmaceutically acceptable salt thereof:
This compound and methods for its preparation are described in WO 2005/116014 and US 7291618.
For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. - (1((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-yl)-1,3,5-triazin-2-yl)pyrrolidin-3-yl)- 5,5-difluoropiperidin-2-one or a pharmaceutically acceptable salt thereof:

This compound and methods for its preparation are described in WO 2007/148185 and US 20070299076. For details, for example, in a process for producing, formulating or using this compound or a salt thereof, reference is thus made to these documents. - (2S,4S)-1 -{2-[(3S, 1R)-3-(1H-1,2,4-triazol-1-ylmethyl)cyclopentylamino]-acetyl}-4-fluoropyrrolidine- 2-carbonitrile (also called melogliptin) or a pharmaceutically acceptable salt thereof:

This compound and methods for its preparation are described in WO 2006/040625 and WO 2008/001195. Salts specifically claimed include methanesulfonate and p-toluenesulfonate. For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. -(R)-2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4 -fluoro-benzonitrile or a pharmaceutically acceptable salt thereof:

This compound and methods for its preparation and use are described in WO 2005/095381, US 2007060530, WO 2007/033350, WO 2007/035629, WO 2007/074884, WO 2007/112368, WO 2008/033851, WO 2008/ 114800 and WO 2008/114807. Salts specifically claimed include succinate (WO 2008/067465), benzoate, benzenesulfonate, p-toluenesulfonate, (R)-mandelate and hydrochloride. For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. - 5-{(S)-2-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-propyl}-5-(1H-) acid bis-dimethylamide tetrazol-5-yl)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-2,8-dicarboxylic acid or a pharmaceutically acceptable salt thereof:

This compound and methods for its preparation are described in WO 2006/116157 and US 2006/270701. For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazin-1 -yl]pyrrolidin-2-ylcarbonyl}thiazolidine (also called teneligliptin) or a pharmaceutically acceptable salt thereof:
This compound and methods for its preparation are described in WO 02/14271. Specific salts are described in WO 2006/088129 and WO 2006/118127 (including hydrochloride, hydrobromide, inter alia). Combination therapy using this compound is described in WO 2006/129785. For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. - [(2R)-1-{[(3R)-pyrrolidin-3-ylamino]acetyl}pyrrolidin-2-yl]boronic acid (also called ductogliptin) or a pharmaceutically acceptable salt thereof:
This compound and methods for its preparation are described in WO 2005/047297, WO 2008/109681 and WO 2009/009751. Specific salts are described in WO 2008/027273 (including citrate, tartrate). A formulation of this compound is described in WO 2008/144730. A formulation of ductogliptin (as its tartrate salt) with metformin is described in WO 2009/091663. For details, for example, on a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. - (2S,4S)-1 -[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1 -yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (also called bisegliptin) or a pharmaceutically acceptable salt of the same:
This compound and methods for its preparation are described in WO 2005/075421, US 2008/146818 and WO 2008/114857. For details, for example, in a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents. - 2-({6-[(3R)-3-amino-3-methylpiperidin-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H -pyrrolo[3,2-d]pyrimidin-5-yl}methyl)-4-fluorobenzonitrile or a pharmaceutically acceptable salt thereof, or 6-[(3R)-3-amino-piperidin-1-yl]-5- (2-chloro-5-fluoro-benzyl)-1,3-d-dimethyl-1,5-dihydro-pyrrole[3,2-d]pyrimidine-2,4-dione or a pharmaceutically acceptable salt of the same:
These compounds and methods for their preparation are described in WO 2009/084497 and WO 2006/068163, respectively. Combination therapy using the latter of these two compounds is described in WO 2009/128360. For details, for example, on a process for the production, formulation or use of these compounds or salts thereof, reference is thus made to these documents. - (S)-2-methylpyrazol[1,5-a]pyrimidin-6-carboxylic acid {2-[(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methylpropyl}amide (also called anagliptin ) or a pharmaceutically acceptable salt:
This compound and methods for its preparation are described in WO 2004/067509. Combination therapy using this compound is described in WO 2009/139362. For details, for example, in a process for the production, formulation or use of this compound or a salt thereof, reference is thus made to these documents.
Preferably, the DPP-4 inhibitor of this invention is selected from the group (group G1) consisting of linagliptin, sitagliptin, vildagliptin, alogliptin, saxagliptin, teneligliptin, anagliptin, gemigliptin and dutogliptin, or a pharmaceutically acceptable salt of one of the DPP-4 inhibitors mentioned herein, or prodrugs thereof.
A particularly preferred DPP-4 inhibitor within the present invention is linagliptin. The term "linagliptin" as used in this application refers to linagliptin or a pharmaceutically acceptable salt thereof, including hydrates and solvates thereof, and crystalline forms thereof, preferably linagliptin refers to 1-[(4-methyl-quinazolin -2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(7')-amino-piperidin-1-yl)-xanthine. Crystal forms are described in WO 2007/128721. Methods for the production of linagliptin are described in patent applications WO 2004/018468 and WO 2006/048427, for example. Linagliptin is distinguished from structurally comparable DPP-4 inhibitors as it combines exceptional potency and a long-lasting effect with favorable pharmacological properties, receptor selectivity and a favorable side-effect profile, or leading to unexpected therapeutic advantages or improvements in mono or mono therapy. dual or triple combination.
For the avoidance of doubt, the description of each of the above-cited documents before and after with respect to the specified DPP-4 inhibitors is specifically incorporated into this application by reference in its entirety.
A long acting insulin within the meaning of the present invention includes, without being limited to, any of those long acting insulins mentioned above and thereafter, preferably long acting insulins active subcutaneously.
Examples of long-acting insulin may include (group G2): insulin glargine; insulin detemir; insulin degludec; insulin lispro PEGylated with high molecular weight poly(ethylene glycol) derivatives as described in WO 2009/152128; amidated insulin glargine in the form of human insulin Gly^1, ArgB31, ArgB32-NH2; LysB29 (Nε-litocholyl-Y-Glu)des(B30) human insulin; NεB29-w-carboxypentadecanoyl-Y-amino-butanoyl des(B30) human insulin; amidated insulin analogues as described in WO 2009/087082 (especially one selected from claim 14 herein), or amidated insulin analogues as described in WO 2009/087081 (especially one selected from claim 16 therein).
Preferred examples of the long-acting insulin of this invention are insulin glargine, insulin detemir and insulin degludec.
Unless otherwise noted, in accordance with this invention, it is to be understood that the definitions of active agents (including DPP-4 inhibitors and long-acting insulin analogues) mentioned above and below may also contemplate their pharmaceutically acceptable salts, and prodrugs, hydrates, solvates and polymorphic forms thereof. Particularly the terms of the therapeutic agents provided in this application refer to the respective active drugs. With respect to salts, hydrates and polymorphic forms thereof, particular reference is made to those referred to in this application.
In one embodiment, the combinations, compositions, methods and uses according to this invention refer to combinations in which the DPP-4 inhibitor and the long acting insulin are preferably selected according to the entries in the Table 1:


In a particular embodiment (modality E), the combinations, compositions, methods and uses according to this invention relate to combinations in which the DPP-4 inhibitor is linagliptin. According to this particular modality (modality E), long-acting insulin is preferably selected according to entries E1 to E3 in Table 2:

Within this invention, it is to be understood that combinations, compositions or combined uses in accordance with this invention may contemplate simultaneous, sequential or separate administration of the active components or ingredients.
In this context, "combination" or "combined" within the meaning of this invention may include, but are not limited to, fixed and non-fixed (e.g., free) forms (including kits) and uses, such as, e.g. -multiple, sequential or separate from the components or ingredients.
The present invention also provides a kit of the parts or combination therapeutic product comprising a) a pharmaceutical composition comprising a DPP-4 inhibitor as defined in this application, optionally together with one or more pharmaceutically acceptable carriers and/or diluents, andb ) a pharmaceutical composition comprising a long-acting insulin as defined in this application.
The present invention also provides a kit comprising a) a DPP-4 inhibitor as defined in this application, and b) a long acting insulin as defined in this application, and, optionally, instructions that guide the use of the DPP-4 inhibitor and the long-acting insulin in combination (for example, simultaneously, separately, sequentially or chronologically staggered), for example, for the purposes of this invention, such as, for example, for the treatment of type 2 diabetes in a (human) patient.
The present invention also provides a pharmaceutical composition or fixed dose combination comprising a) a DPP-4 inhibitor as defined in this application, and b) a long acting insulin as defined in this application, and optionally one or more vehicles and /or pharmaceutically acceptable diluents.
The present invention also provides a transdermal or subcutaneous (injectable) pharmaceutical composition, delivery system or device for systemic use comprising a) a DPP-4 inhibitor as defined in this application, and, optionally, b) a long acting insulin as defined in this application, and optionally one or more pharmaceutically acceptable carriers and/or diluents.
The combined administration of this invention can be accomplished by administering the active components or ingredients together, such as, for example, administering them simultaneously in a single formulation or in two separate or dosage forms. Alternatively, administration may be carried out by administering the active components or ingredients sequentially, such as, for example, successively in two separate formulations or dosage forms.
For the combination therapy of this invention, the active components or ingredients can be administered separately (which implies that they are formulated separately) or formulated completely (which implies that they are formulated in the same preparation or in the same dosage form). Therefore, administration of one element of the combination of the present invention may be prior to, simultaneous with, or subsequent to administration of another element of the combination. In one embodiment, for the combination therapy according to this invention, the DPP-4 inhibitor and the long acting insulin are administered in different formulations or different dosage forms. In another embodiment, for the combination therapy according to this invention, the DPP-4 inhibitor and the long acting insulin are administered in the same formulation or in the same dosage form.
Unless otherwise noted, combination therapy may refer to first-line, second-line, or third-line therapy, or initial or adjunct to combination therapy or replacement therapy.
With respect to embodiment A, methods of synthesizing DPP-4 inhibitors according to embodiment A of this invention are known to the skilled person. Advantageously, DPP-4 inhibitors according to embodiment A of this invention can be prepared using synthetic methods as described in the literature. Thus, for example, purine derivatives of formula (I) can be obtained as described in WO 2002/068420, WO 2004/018468, WO 2005/085246, WO 2006/029769 or WO 2006/048427, the disclosures of which are incorporated in this application. Purine derivatives of formula (II) can be obtained as described, for example, in WO 2004/050658 or WO 2005/110999, the disclosures of which are incorporated in this application. Purine derivatives of formula (III) and (IV) can be obtained as described, for example, in WO 2006/068163, WO 2007/071738 or WO 2008/017670, the disclosures of which are incorporated in this application. The preparation of those DPP-4 inhibitors, which are specifically mentioned above, is described in the publications mentioned in connection thereto. Modifications of polymorph crystals and formulations of particular DPP-4 inhibitors are described in WO 2007/128721 and WO 2007/128724, respectively, the disclosures of which are incorporated in this application in their entirety. Particular formulations of DPP-4 inhibitors with metformin or other combination partners are described in WO 2009/121945, the description of which is incorporated into this application in its entirety.
The typical dosage of the dual fixed combination (tablet) of lina-gliptin / metformin IR (immediate release) is 2.5/500 mg, 2.5/850 mg and 2.5/1000 mg, which can be administered 1-3 times a day, particularly twice a day.
The typical dosage of the dual fixed combination (tablet) of lina-gliptin / metformin XR (extended release) is 5/500 mg, 5/1000 mg and 5/1500 mg (each tablet) or 2.5/500 mg, 2, 5/750 mg and 2.5/1000 mg (each two tablets), which can be administered 1-2 times a day, particularly once a day, preferably to be taken in the afternoon with a meal.
The present invention further provides a DPP-4 inhibitor as defined in this application for use (complement or initial) in combination therapy with metformin (e.g., in a total daily amount of metformin hydrochloride from 500 to 2000 mg, such as , for example 500mg, 850mg or 1000mg once or twice a day).
With respect to modality B, methods of synthesis of modality B DPP-4 inhibitors are described in the scientific literature and/or in published patent documents, particularly those cited in this application.
The combination elements of this invention can be administered in various ways, eg, by oral, buccal, sublingual, enteric, parenteral (e.g., transdermal, intramuscular or subcutaneous), inhalatory (e.g., liquid inhalation or powder, aerosol), pulmonary, intranasal (eg, spray), intraperitoneal, vaginal, rectal, or topical routes for administration and may be formulated, alone or together, into suitable unit dosage formulations containing vehicles, suitable non-toxic conventional pharmaceutically acceptable adjuvants and carriers for each route of administration.
In a preferred embodiment, the DPP-4 inhibitor component of the combination according to the invention is preferably administered orally; In another preferred embodiment, the long-acting insulin component of the combination is preferably administered by injection (preferably subcutaneously). In another embodiment, the long-acting insulin component of the combination is administered via a transdermal delivery system.
Suitable doses and dosage forms of the DPP-4 inhibitors can be determined by one of skill in the art and can include those described in this application or in the relevant references.
For pharmaceutical application in warm-blooded vertebrates, particularly humans, the compounds of this invention are normally used in dosages of 0.001 to 100 mg/kg body weight, preferably in 0.01-15 mg/kg or 0. 1-15 mg/kg, in each case 1 to 4 times a day. For this purpose, the compounds, optionally combined with other active substances, can be incorporated together with one or more inert conventional carriers and/or diluents, for example, with corn starch, lactose, glucose, microcrystalline cellulose, magnesium stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water, water/ethanol, water/glycerol, water/sorbitol, water/polyethylene glycol, propylene glycol, cetilestearyl alcohol, carboxymethylcellulose or fatty substances such as hard fats or suitable mixtures thereof in conventional galenic preparations such as plain or coated tablets, capsules, powders, suspensions or suppositories.
Pharmaceutical compositions according to this invention comprising the DPP-4 inhibitors as defined in this application are thus prepared by the skilled person using pharmaceutically acceptable formulation excipients as described in the art and suitable for the desired route of administration. Examples of such excipients include, but are not limited to, diluents, binders, vehicles, fillers, lubricants, flow promoters, crystallization delays, disintegrants, solubilizers, colorants, pH regulators, surfactants and emulsifiers.
Oral preparations or dosage forms of the DPP-4 inhibitor of this invention can be prepared according to known techniques.
Examples of suitable diluents of compounds according to modality A include cellulose powder, calcium hydrogen phosphate, erythritol, low substituted hydroxypropyl cellulose, mannitol, pregelatinized starch or xylitol.
Examples of suitable lubricants of compounds according to modality A include talc, polyethylene glycol, calcium behenate, calcium stearate, magnesium stearate or hydrogenated castor oil.
Examples of suitable binders of compounds according to modality A include copovidone (copolymerisates of vinylpyrrolidone with other vinyl derivatives), hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose (HPC), polyvinylpyrrolidone (povidone), pregelatinized starch, or low hydroxypropylcellulose replaced (L-HPC).
Examples of suitable disintegrants of compounds according to modality A include corn starch or crospovidone.
Suitable methods of preparing pharmaceutical formulations of the DPP-4 inhibitors according to embodiment one of the invention are direct tableting of the active substance in powder mixes with suitable tableting excipients; • granulation with suitable excipients and subsequent mixing with suitable excipients and subsequent tableting as well as film coating; or • packaging powder or granule mixtures in capsules.
Suitable granulation methods are • wet granulation in the intensive mixer followed by fluid bed drying; • granulation of a vessel; • fluidized bed granulation; or • dry granulation (eg by roller compaction) with suitable excipients and subsequent tableting or filling into capsules.
An exemplary composition (e.g., tablet core) of a DPP-4 inhibitor according to embodiment A of the invention comprises the first diluent mannitol, pregelatinized starch as a second diluent with additional binder properties, the binder copovidone, the disintegrant corn starch, and magnesium stearate as a lubricant; wherein copovidone and/or cornstarch may be optional.
A tablet of a DPP-4 inhibitor according to modality A of the invention may be film coated, preferably the film coating comprises hydroxypropylmethylcellulose (HPMC), polyethylene glycol (PEG), talc, titanium dioxide and iron oxide (eg red and/or yellow).
In a further embodiment, the DPP-4 inhibitor component of the combination according to the invention is administered by injection (preferably subcutaneously). In another embodiment, the long-acting insulin component of the combination is preferably administered by injection (preferably subcutaneously) as well. In another embodiment, the long-acting insulin component of the combination is administered via a transdermal delivery system.
Injectable formulations of the long-acting insulin and/or DPP-4 inhibitor of this invention (particularly for subcutaneous use) may be prepared according to known formulation techniques, for example, using suitable liquid carriers, which normally comprise water sterile, and, optionally, additional additives such as, for example, preservatives, pH adjusting agents, buffering agents, isotonifying agents, solubility aids and/or surfactants or the like, to obtain injectable solutions or suspensions. Furthermore, injectable formulations may comprise additional additives, eg salts, solubility modifying agents or precipitating agents that delay the release of the drug(s). Furthermore, injectable insulin formulations can comprise insulin stabilizing agents, such as zinc compounds.
In a further embodiment, the DPP-4 inhibitor component of the combination according to the invention is administered by a transdermal delivery system. In another embodiment, the long-acting insulin component of the combination is administered by a transdermal delivery system as well. In another embodiment, the long-acting insulin component of the combination is preferably administered by injection (preferably subcutaneously). In another modality, the long-acting insulin component of the combination is administered by insulin precipitates (implanted subcutaneously).
Transdermal formulations (eg for transdermal patches or gels) of the long-acting insulin and/or DPP-4 inhibitor of this invention can be prepared according to known formulation techniques, for example, using suitable carriers and optionally , additional additives. To facilitate transdermal passage, different methodologies and systems can be used, such as, for example, techniques that involve the formation of microchannels or micropores in the skin, such as, for example, iontophoresis (based on low-level electrical current) , sonophoresis (based on low-frequency ultrasound) or microneedles, or use of drug carrier agents (eg, elastic or lipid vesicles, such as transfersomes) or permeation enhancers.
For further details of dosage forms, formulations and administration of DPP-4 inhibitors of this invention and/or long acting insulin of this invention, reference is made to the scientific literature and/or published patent documents, particularly those cited in this application .
Pharmaceutical compositions (or formulations) can be packaged in a variety of ways. Generally, an article for distribution includes one or more containers that contain one or more pharmaceutical compositions in an appropriate form. The tablets are typically packaged in an appropriate primary package for easy handling, distribution and storage and to ensure the composition's proper stability in prolonged contact with the environment during storage. Primary pill containers can be bottles or blisters.
A bottle suitable, for example, for a pharmaceutical composition or combination (tablet) comprising a DPP-4 inhibitor according to embodiment A of the invention, may be made of glass or polymer (preferably polypropylene (PP) or high density polyethylene. (HD-PE)) and sealed with a screw-on cap. The screw-on cover can be provided with a child-resistant safety closure (eg pinch-and-swivel closure) to prevent or prevent access to the contents by children. If necessary (eg in regions with high humidity), by additional use of a desiccant (such as, for example, bentonite clay, molecular sieves, or preferably silica gel) the shelf life of the packaged composition can be extended .
A blister suitable, for example, for a pharmaceutical composition or combination (tablet) which comprises a DPP-4 inhibitor according to embodiment one of the invention, comprises or is formed of a topsheet (which is breakable by the tablets) and a bottom (containing the pill area). The top sheet may contain a metal sheet, particularly aluminum or aluminum alloy sheet (for example, having a thickness of 20 µm to 45 µm, preferably 20 µm to 25 µm) that is covered with a heat-sealed polymer layer on its inner side (sealing side). The underside may contain a multilayer polymer sheet (such as, for example, polyvinyl chloride (PVC) coated with polyvinylidene chloride (PVDC); or a PVC sheet laminated with poly(chlorotriflouroethylene) ( PCTFE)) or a metal polymer sheet of the multi-layer polymer (such as, for example, a cold molded laminated PVC/aluminium/polyamide composition).
To ensure a long storage period especially under hot and humid climate conditions an additional cover or pouch made of a multi-layer polymer metallic polymer sheet (eg a polyethylene/aluminium/polyester laminated composition) can be used to the blisters. The supplemental desiccant (such as, for example, bentonite clay, molecular sieves, or, preferably, silica gel) in this bag can further prolong shelf life even under such adverse conditions.
Injection solutions may be available in typical suitable presentation forms, such as pre-filled (disposable) vials, cartridges or pens, which may be further packaged.
The article may further comprise a label or package insert, which refers to instructions commonly included in commercial packages of therapeutic products, which may contain information about the indications, use, dosage, administration, contraindications and/or warnings about the use of such therapeutic products. In one embodiment, the package inserts or markers indicate that the composition can be used for any of the purposes described in this application.
With respect to the first modality (modality A), the typically required dosage of the DPP-4 inhibitors mentioned in this application in the modality when administered intravenously is 0.1 mg to 10 mg, preferably 0.25 mg to 5 mg, and when administered orally is 0.5mg to 100mg, preferably 2.5mg to 50mg or 0.5mg to 10mg, more preferably 2.5mg to 10mg or 1mg to 5mg, in each case 1 to 4 times per morning. Thus, for example, the dosage of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R) -amino-piperidin-1-yl)-xanthine when administered orally is 0.5 mg to 10 mg per patient per day, preferably 2.5 mg to 10 mg or 1 mg to 5 mg per patient per day.
A dosage form prepared with a pharmaceutical composition comprising a DPP-4 inhibitor mentioned in this application in modality A contains the active ingredient in a dosage range of 0.1-100 mg. Thus, for example, particular oral dosages of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R) )-amino-piperidin-1-yl)-xanthine are 0.5 mg, 1 mg, 2.5 mg, 5 mg and 10 mg.
With respect to the second modality (modality B), the doses of the DPP-4 inhibitors mentioned in this application in modality B to be administered to mammals, e.g. humans, e.g., of body weight of approximately 70 kg, can generally be from approximately 0.5 mg to approximately 350 mg, for example from approximately 10 mg to approximately 250 mg, preferably 20-200 mg, more preferably 20-100 mg, of the active portion per person per day, or of approximately 0.5mg to approximately 20mg, preferably 2.5-10mg, per person per day, preferably divided into 1 to 4 single doses which, for example, may be of the same size. Single oral dosages comprise, for example, 10, 25, 40, 50, 75, 100, 150 and 200 mg of the active portion of the DPP-4 inhibitor.
An oral dosage strength of the DPP-4 inhibitor sitagliptin is typically between 25 and 200 mg of the active portion. A recommended dose of sitagliptin is 100 mg calculated for the active portion (anhydrate free base) once daily. Unit dosages of sitagliptin anhydrate free base (active portion) are 25, 50, 75, 100, 150 and 200 mg. The particular unit dosage of sitagliptin (eg per tablet) is 25, 50 and 100 mg. An equivalent amount of sitagliptin phosphate monohydrate to sitagliptin anhydrate free base is used in the pharmaceutical compositions, namely 32.13, 64.25, 96.38, 128.5, 192.75, and 257 mg, respectively. Adjusted dosages of 25 and 50 mg sitagliptin are used for patients with renal failure. The typical dosage of the dual sitagliptin/metformin combination is 50/500 mg and 50/1000 mg.
An oral dosage range of the DPP-4 inhibitor vildagliptin is normally between 10 and 150 mg daily, in particular between 25 and 150 mg, 25 and 100 mg or 25 and 50 mg or 50 and 100 mg daily. Particular examples of the daily oral dosage are 25, 30, 35, 45, 50, 55, 60, 80, 100 or 150 mg. In a more particular aspect, the daily administration of vildagliptin may be between 25 and 150 mg or between 50 and 100 mg. In another more particular aspect, the daily administration of vildagliptin may be 50 or 100 mg. The application of the active ingredient can take place up to three times a day, preferably once or twice a day. The particular dosage is 50mg or 100mg of vildagliptin. The typical dosage of the dual combination of vildagliptin / metformin is 50/850 mg and 50/1000 mg.
Alogliptin can be administered to a patient at a daily oral dose of between 5 mg/day and 250 mg/day, optionally between 10 mg and 200 mg, optionally between 10 mg and 150 mg, and optionally between 10 mg and 100 mg of alogliptin (in each example based on the molecular weight of the free base form of alogliptin). Thus, specific oral dosage amounts that can be used include, but are not limited to, 10 mg, 12.5 mg, 20 mg, 25 mg, 50 mg, 75 mg, and 100 mg of alogliptin per day. Alogliptin can be administered in its free base form or as a pharmaceutically acceptable salt.
Saxagliptin can be administered to a patient at a daily oral dose between 2.5 mg/day and 100 mg/day, optionally between 2.5 mg and 50 mg. Specific oral dosage amounts that can be used include, but are not limited to, 2.5 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 100 mg of saxagliptin per day. The typical dosage of the dual combination of saxagliptin I metformin is 2.5/500 mg and 2.5/1000 mg.
A special embodiment of the DPP-4 inhibitors of this invention relates to those orally administered DPP-4 inhibitors that are therapeutically effective at low dose levels, for example, at oral dose levels <100 mg or <70 mg per patient per day, preferably <50 mg, more preferably <30 mg or <20 mg, even more preferably from 1 mg to 10 mg, particularly from 1 mg to 5 mg (more particularly 5 mg), per patient per day (if necessary divided in 1 to 4 single doses, particularly 1 or 2 single doses, which may be of the same size, preferably given orally a few times a day (more preferably once a day), advantageously given at any time of the day, with or without Thus, for example, the daily oral amount of 5 mg BI 1356 can be delivered in a once-daily dosing regimen (ie, 5 mg BI 1356 once a day) or in a twice daily dosing regimen (ie, 2.5 mg of BI 1356 twice a day), at any time of the day, with or without food.
Long-acting insulin is typically given by subcutaneous injection, for example, ranging from twice a day, once a day to once a week injection. Appropriate doses and long-acting insulin dosage forms can be determined by one of skill in the art. Blood glucose monitoring is essential in all patients receiving insulin therapy.
For example, insulin glargine (Lantus) is given subcutaneously once a day. Lantus can be administered at any time during the day, but at the same time each day. The Lantus dose is individualized based on clinical response. The recommended starting dose of Lan-tus in patients with type 2 diabetes who are not currently being treated with insulin is 10 units (or 0.2 Unit/kg) once daily, which should be further adjusted to the patient's needs.
Insulin detemir (Levemir) is given subcutaneously once or twice a day. For patients treated with Levemir once daily, the dose is preferably administered with the afternoon meal or at bedtime. For patients who require twice-daily dosing, the evening dose can be administered with the evening meal, at bedtime, or 12 hours after the morning dose. The dose of Levemir is individualized based on clinical response. For insulin-pure type 2 diabetes patients who are inadequately controlled with oral antidiabetic drugs, Levemir should be started at a dose of 0.1 to 0.2 Unit/kg once daily at night or 10 units once or twice per day, and the dose adjusted to achieve glycemic goals.
The dosage of the active ingredients in the combinations and compositions according to the present invention can be varied, although the amount of the active ingredients must be such that a suitable dosage form is obtained. Therefore, the dosage selected and the dosage form selected from should depend on the desired therapeutic effect, the route of administration and the duration of treatment. Suitable dosage ranges for combination are from the maximum tolerated dose of the single agent to reduced doses, for example, to one-tenth of the maximum tolerated dose.
A particularly preferred DPP-4 inhibitor to be emphasized within the meaning of this invention is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)- 8-(3-(/ )-amino-piperidin-1-yl)-xanthine (also known as BI 1356 or linagliptin). BI 1356 exhibits high potency, 24 h duration of action, and a wide therapeutic window. In patients with type 2 diabetes who receive multiple oral doses of 1, 2.5, 5 or 10 mg of BI 1356 once daily for 12 days, BI 1356 shows a favorable pharmacodynamic and pharmacokinetic profile (see eg table 3 below) with rapid attainment of steady state (eg, reaching constant steady state plasma levels (> 90% of pre-dose plasma concentration on Day 13) between the second and fifth day of treatment in all dose groups), little accumulation ( eg with a mean RA accumulation ratio, AUC ^1.4 at doses above 1 mg) and retaining a long-lasting effect on DPP-4 inhibition (eg with almost complete (> 90%) inhibition of DPP-4 at the 5 mg and 10 mg dose levels, i.e., 92.3 and 97.3% inhibition in the steady state, respectively, and >80% inhibition over a 24 h interval after entry of drug), as well as a significant reduction in postprandial 2-h blood glucose excursions by >80% (already on Day 1) at doses 2.5 mg, and with cumulative amount of unchanged parent compound excreted in urine on Day 1 being below 1% of the administered dose and increasing to no more than approximately 3-6% on Day 12 (CLR,SS renal clearance is approximately 14 to approximately 70 ml/min of the administered oral doses, for example, of the 5 mg dose the renal clearance is approximately 70 ml/min). In people with type 2 diabetes, BI 1356 shows similar safety and tolerability to placebo. At low doses of approximately 5 mg, BI 1356 acts as a true once-daily oral drug with a full 24 h duration of DPP-4 inhibition. At therapeutic levels of oral dose, BI 1356 is mainly excreted via the liver and only to a lesser extent (approximately <7% of the administered oral dose) via the kidney. BI 1356 is mainly excreted unchanged through the bile. The fraction of BI 1356 eliminated via the kidneys increases only very slightly over time and with increasing dose, so that there is probably no need to modify the dose of BI 1356 based on the patients' renal function. Non-renal elimination of BI 1356 in combination with its low potential accumulation and wide safety margin may be of significant benefit in a population of patients who have a high prevalence of renal failure and diabetic nephropathy. Table 3: Geometric mean (gMean) and geometric coefficient of variation (gCV) of steady state BI 1356 pharmacokinetic parameters (Day 12)


As different metabolic functional disturbances often occur simultaneously, it is often very appropriate to combine several different active principles with each other. Thus, depending on the functional disorders, improved diagnosed treatment outcomes can be obtained if a DPP-4 inhibitor is combined with usual active substances for the respective disorders, such as, for example, one or more active substances selected from other antidiabetic substances, especially active substances that reduce the blood sugar level or blood lipid level, increase the blood HDL level, reduce blood pressure, or are indicated in the treatment of atherosclerosis or obesity.
The DPP-4 inhibitors mentioned above - in addition to their use in monotherapy - can also be used in conjunction with other active substances, whereby improved treatment results can be obtained. Such combined treatment can be given as a free combination of the substances or in the form of a fixed combination, for example, in a tablet or capsule. Pharmaceutical formulations of the combination partner necessary for this can be obtained commercially as pharmaceutical compositions or can be formulated by the expert using conventional methods. Active substances that are commercially obtainable as pharmaceutical compositions are described in numerous places in the prior art, for example, in the annually appearing drug list, the "Rote Liste®" of the federal pharmaceutical industry association, or in the annually updated compilation of information from the prescription drug manufacturers known as "The Physicians' Desk Reference".
Examples of antidiabetic combination partners are met-formin; sulfonylureas such as glibenclamide, tolbutamide, glimepiride, glipizide, gliquidone, glibornuride and gliclazide; nateglinide; repaglinide; mitiglinide; thiazolidinediones such as rosiglitazone and pioglitazone; PPAR gamma modulators such as metaglidases; PPAR-gamma agonists such as, for example, rivoglitazone, mitoglitazone, INT-131 and balaglitazone; PPAR-gamma antagonists; PPAR-gamma/alpha modulators such as tesaglitazar, muraglitazar, aleglitazar, indeglitazar, and KRP297; PPAR-gamma/alpha/delta modulators such as, for example, lobeglitazone; AMPK activators such as AICAR; acetyl-CoA carboxylase inhibitors (ACC1 and ACC2); diacylglycerol acetyltransferase (DGAT) inhibitors; pancreatic beta cell GCRP agonists such as SMT3 and GPR119 receptor agonists such as the GPR119 agonists 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol- 2-yl]-piperidin-1-yl}-pyrimidine or 5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-ylmethoxy]-2-(4- methanesulfonyl-phenyl)-pyridine; 11β-HSD inhibitors; FGF19 agonists or analogues; alpha-glycosidase blockers such as acarbose, voglibose and miglitol; alpha2 antagonists; insulin and insulin analogues such as human insulin, insulin lispro, insulin glusilin, r-DNA-insulinspart, NPH insulin, insulin detemir, insulin degludec, insulin tregopil, insulin zinc suspension and insulin glargine; Gastric Inhibitory Peptide (GIP); amylin and amylin analogues (for example, pramlintide or davalintide); GLP-1 and GLP-1 analogues such as Exendin-4, e.g. exenatide, exenatide LAR, liraglutide, taspoglutide, lixisenatide (AVE-0010), LY-2428757 (a PEGylated version of GLP-1), du- laglutide (LY-2189265), semaglutide or albiglutide; SGLT2 inhibitors such as, for example, dapagliflozin, sergliflozin (KGT-1251), atigliflozin, canagliflozin, ipragliflozin, luseogliflozin or tofogliflozin; protein tyrosine phosphatase inhibitors (for example, troduschemine); glucose-6-phosphatase inhibitors; fructose-1,6-bisphosphatase modulators; glycogen phosphorylase modulators; glucagon receptor antagonists; phosphoenolpyruvatecarboxykinase (PEPCK) inhibitors; pyruvate dehydrogenasequinase (PDK) inhibitors; inhibitors of tyrosine kinases (50mg to 600mg), such as PDGF-receptor kinase (cf. EP-A-564409, WO 98/35958, US 5093330, WO 2004/005281, and WO 2006/041976) or serine /threonine kinases; glycokinase/regulatory protein modulators incl. glycokinase activators; glycogen synthase kinase inhibitors; inhibitors of inositol 5 phosphatase type 2 containing SH2 domain (SHIP2); IKK inhibitors such as high dose salicylate; JNK1 inhibitors; protein kinase C-theta inhibitors; beta 3 agonists such as ritobegron, YM 178, solabegron, talibegron, N-5984, GRC-1087, rafabegron, FMP825; aldose reductase inhibitors such as AS-3201, zenarestat, fidarestat, epalrestat, ranirestat, NZ-314, GP-744809, and CT-112; SGLT-1 or SGLT-2 inhibitors; KV 1.3 channel inhibitors; GPR40 modulators such as, for example, [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3 acid -dihydro-1-benzofuran-3-yl]acetic; SCD-1 inhibitors; CCR-2 antagonists; dopamine receptor agonists (bromocriptine mesylate [Cicloset]); 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutanoic acid; sirtuin stimulants; and other DPP IV inhibitors.
Metformin is usually given in doses ranging from approximately 500 mg to 2000 mg to 2500 mg per day using various dosing regimens from approximately 100 mg to 500 mg or 200 mg to 850 mg (1-3 times daily), or approximately 300 mg to 1000 mg once or twice daily, or delayed release metformin in doses of approximately 100 mg to 1000 mg or preferably 500 mg to 1000 mg once or twice daily or approximately 500 mg to 2000 mg once daily morning. Particular dosages may be 250, 500, 625, 750, 850 and 1000 mg of metformin hydrochloride.
For children 10 to 16 years of age, the recommended starting dose of metformin is 500 mg given once daily. If this dose fails to produce adequate results, the dose may be increased to 500 mg twice a day. Further increases can be made in increments of 500 mg per week to a maximum daily dose of 2000 mg, given in divided doses (eg 2 or 3 divided doses). Metformin can be taken with food to reduce nausea.
A dosage of pioglitazone is usually approximately 1-10 mg, 15 mg, 30 mg, or 45 mg once daily.
Rosiglitazone is usually given in doses of 4 to 8 mg once (or divided twice) daily (typical dosage is 2, 4 and 8 mg).
Glibenclamide (glyburide) is usually given in doses of 2.5-5 to 20 mg once (or divided twice) daily (typical dosage is 1.25, 2.5 and 5 mg), or micronized glibenclamide in doses of 0.75-3 to 12 mg once (or divided twice) daily (typical dosages are 1.5, 3.4.5 and 6 mg).
Glipizide is usually given in doses of 2.5 to 10-20 mg once (or up to 40 mg divided into twice) daily (typical dosage is 5 and 10 mg), or extended-release glibenclamide in doses of 5 to 10 mg (up to 20 mg) once a day (typical dosage is 2.5, 5 and 10 mg).
Glimepiride is usually given in doses of 1-2 to 4 mg (up to 8 mg) once daily (typical dosage is 1, 2 and 4 mg).
A dual combination of glibenclamide/metformin is usually given in doses from 1.25/250 once daily to 10/1000 mg twice daily. (typical dosage is 1.25/250, 2.5/500 and 5/500 mg).
A dual combination of glipizide/metformin is usually given in doses of 2.5/250 to 10/1000 mg twice a day (typical dosage is 2.5/250, 2.5/500 and 5/500 mg).
A dual combination of glimepiride/metformin is usually given in doses of 1/250 to 4/1000 mg twice a day.
A dual combination of rosiglitazone/glimepiride is usually given in doses of 4/1 once or twice daily to 4/2 mg twice daily (typical dosages are 4/1.4/2, 4/4, 8/2 and 8/4 mg).
A dual combination of pioglitazone/glimepiride is usually given in doses of 30/2 to 30/4 mg once daily (typical dosage is 30/4 and 45/4 mg).
A dual combination of rosiglitazone/metformin is usually given in doses of 1/500 to 4/1000 mg twice daily (typical dosage is 1/500, 2/500, 4/500, 2/1000 and 4/1000 mg) .
A dual combination of pioglitazone/metformin is usually given in doses of 15/500 once or twice daily to 15/850 mg three times daily (typical dosage is 15/500 and 15/850 mg).
The non-sulfonylurea insulin secretagogue nateglinide is usually given in doses of 60 to 120 mg with meals (up to 360 mg/day, typical dosage is 60 and 120 mg); repaglinide is usually given in doses of 0.5 to 4 mg with meals (up to 16 mg/day, typical dosage is 0.5, 1 and 2 mg). A dual repaglinide/metformin combination is available in strengths of 1/500 and 2/850 mg.
Acarbose is usually given in doses of 25 to 100 mg with meals. Miglitol is usually given in doses of 25 to 100 mg with meals.
Examples of combination partners that reduce the blood lipid level are HMG-CoA-reductase inhibitors such as simvastatin, atorvastatin, lovastatin, fluvastatin, pravastatin, pitavastatin and rosuvastatin; fibrates such as bezafibrate, fenofibrate, clofibrate, gemfibrozil, etofibrate and ethofilinclofibrate; nicotinic acid and derivatives thereof such as acipimox; PPAR-alpha agonists; PPAR-delta agonists such as, for example, {4-[(R)-2-ethoxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid; acyl-coenzyme A:cholesterolacyltransferase (ACAT; EC 2.3.1.26) inhibitors such as avasimibe; cholesterol resorption inhibitors such as ezetimibe; bile acid binding substances such as cholestyramine, colestipol and colesevelam; bile acid transport inhibitors; HDL modulating active substances such as D4F, reverse D4F, LXR modulating active substances and FXR modulating active substances; CETP inhibitors such as torcetrapib, JTT-705 (dalcetrapib) or compound 12 of WO 2007/005572 (anacetrapib); LDL receptor modulators; MTP inhibitors (for example lomitapide); and ApoB100 antisense RNA.
A dosage of atorvastatin is usually 1 mg to 40 mg or 10 mg to 80 mg once a day.
Examples of combination partners that lower blood pressure are beta blockers such as atenolol, bisoprolol, celiprolol, metoprolol and carvedilol; diuretics such as hydrochlorothiazide, chlorthalidone, xipamide, furosemide, piretanide, torasemide, spironolactone, eplerenone, amiloride and triamterene; calcium channel blockers such as amlodipine, nifedipine, nitrendipine, nisoldipine, nicardipine, felodipine, lacidipine, lercanipidine, manidipine, isradipine, nilvadipine, verapamil, gallopamil and dilti-azem; ACE inhibitors such as ramipril, lisinopril, cilazapril, quinapril, captopril, enalapril, benazepril, perindopril, fosinopril and trandolapril; as well as angiotensin II receptor blockers (ARBs) such as telmisartan, candesartan, valsartan, losartan, irbesartan, olmesartan, azilsartan, and eprosartan.
A dosage of telmisartan is usually 20 mg to 320 mg or 40 mg to 160 mg per day.
Examples of combination partners that increase the level of HDL in the blood are Cholesteryl Ester Transfer Protein (CETP) inhibitors; endothelial lipase inhibitors; ABC1 regulators; antagonists of LXRalpha; LXRbeta agonists; PPAR-delta agonists; LXRalpha/beta regulators, and substances that increase the expression and/or plasma concentration of apolipoprotein "A-1".
Examples of combination partners for the treatment of obesity are sibutramine; tetrahydrolipstatin (orlistat); alizyme (cetistat); dexfenfluramine; axoquine; cannabinoid receptor 1 antagonists, such as the CB1 antagonist rimonabant; MCH-1 receptor antagonists; MC4 receptor agonists; NPY5 as well as NPY2 antagonists (eg velneperit); beta3-AR agonists such as SB-418790 and AD 9677; 5HT2c receptor agonists such as APD 356 (lorcaserin); myostatin inhibitors; Acrp30 and adiponectin; sterol CoA desaturase (SCD1) inhibitors; fatty acid synthase (FA) inhibitors; CCK receptor agonists; Ghrelin receptor modulators; Pyy 3-36; orexin receptor antagonists; and tesofensin; as well as dual combinations bupropion/naltrexone, bupropion/zonisamide, topiramate/phentermine and pramlintide/metreleptin.
Examples of combination partners for the treatment of atherosclerosis are phospholipase A2 inhibitors; tyrosine kinase inhibitors (50mg to 600mg) such as PDGF-receptor kinase (cf. EP-A-564409, WO 98/35958, US 5093330, WO 2004/005281, and WO 2006/041976); oxLDL antibodies and oxLDL vaccines; apoA-1 Milano; WING; and VCAM-1 inhibitors.
The present invention is not to be limited in scope by the specific embodiments described in this application. Various modifications of the invention in addition to those described in this application may be apparent to those skilled in the art in the present description. Such modifications are intended to be included within the scope of the appended claims.
All patent applications cited in this application are hereby incorporated by reference in their entirety.
Additional modalities, attributes and advantages of the present invention may be evident from the following examples. The following examples serve to illustrate, by way of example, the principles of the invention without restricting it. Examples Dosage of Linagliptin s.c. and its inhibition of DPP-4 in plasma
Subcutaneous (s.c) linagliptin dose. and plasma DPP-4 inhibition may be comparable in efficacy and duration of action to oral dosing, 5 which may make it suitable for use in fixed combination with s.c. insulin:
Male ZDF rats (n=5) were treated with different concentrations of BI 1356 in a regimen of subcutaneous (s.c) administration. (0.001 mg/kg, 0.01 mg/kg, 0.1 mg/kg and 1 mg/kg in 0.5 ml/kg NaCl solution) compared to 3 mg/kg p.o. (in 0.5% Natrosol, application volume 5 ml/kg).
DPP-4 activity in plasma EDTA was detected 1,3,5, 7, 24, 31, 48, 72 h following drug administration (blood was taken by venipuncture under isoflurane anesthesia of the sublingual vein).
B11356 doses of 0.01 mg/kg (administered s.c.) in significant inhibition demonstrated DPP-4 activity compared to control. The 0.1 mg/kg and 1 mg/kg dose (s.c. administration) of B11356 had a persistent DPP-4 inhibition of greater than 64% over 7 h. Dose 1 mg/kg s.c. was comparable in efficacy and duration of action to the oral dose of 3 mg/kg.
Figure 1 demonstrates DPP-4 activity in plasma after linagliptin s.c. Effect of linagliptin on body weight, total body fat, liver fat and intramyocellular fat
In an additional study the efficacy of chronic treatment with li-nagliptin on body weight, total body fat, intramyocellular fat and liver fat in a non-diabetic model of diet-induced obesity (DIO) compared to the appetite suppressant sibutramine is investigated:
Rats are fed a high-fat diet for 3 months and given vehicle, linagliptin (10 mg/kg), or sibutramine (5 mg/kg) for an additional 6-30 weeks, continuing the high-fat diet. Magnetic resonance spectroscopy (NMR) for h after administration of total body, muscle fat, and liver fat is performed before treatment and at the end of the study.
Sibutramine causes a significant reduction in body weight (- 12%) against the control, whereas linagliptin has no significant effect (-3%). Total body fat is also significantly reduced by sibutramine (-12%), whereas animals treated with linagliptin show no significant reduction (-5%). However, linagliptin and sibutramine result in both a potent reduction of intramyocellular fat (-24% and -34%, respectively). Furthermore, treatment with linagliptin results in a profound reduction in liver fat (-39%), whereas the effect of sibutramine (-30%) does not reach significance (see Table 4). Thus, linagliptin is weight neutral, but improves intramyocellular and hepatic lipid accumulation.

Finally, linagliptin treatment causes a potent reduction in intramyocellular lipids and liver fat, which are both independent of weight loss. The effects of sibutramine on muscle and liver fat are mainly attributed to the known weight reduction induced by this compound. Delaying the onset of diabetes and conserving beta cell function in non-obese type 1 diabetes:
Although reduced pancreatic T cell migration and altered cytokine production are considered important participants in the onset of insulinitis, the exact mechanism and effects on pancreatic cell grouping are not fully understood. In an attempt to assess the effect of linagliptin on pancreatic inflammation and beta cell mass, the progression of diabetes in "non-obese diabetic" (NOD) mice over a 60-day experimental period coupled with terminal stereological assessment of pancreatic cellular changes is examined. .
Sixty female NOD mice (10 weeks of age) are included in the study and fed a normal chow diet or a diet containing linagliptin (0.083 g linagliptin/kg feed; corresponding to 3-10 mg/kg, po) over the course of the period. study period. Biweekly plasma samples are obtained to determine the onset of diabetes (BG >11 mmol/l). Upon completion, the pancreas are removed and a terminal blood sample is obtained to assess active GLP-1 levels.
At the end of the study period, the incidence of diabetes is significantly reduced in mice treated with linagliptin (9 of 30 mice) compared to the control group (18 of 30 mice, p=0.021). Subsequent stereological assessment of beta cell mass (identified by insulin immunoreactivity) demonstrates a significantly greater beta cell mass (vehicle 0.18 ± 0.03 mg; linagliptin 0.48 ± 0.09 mg, p < 0.01 ) and total islet mass (vehicle 0.40 ± 0.04 mg; linagliptin 0.70 ± 0.09 mg, p < 0.01) in mice treated with linagliptin. There is a tendency for linagliptin to reduce peri-islet infiltrating lymphocytes (1.06 ± 0.15; lina 0.79 ± 0.12 mg, p=0.17). As expected active plasma GLP-1 is highest in the end in mice treated with linagliptin.
In summary, the data demonstrate that linagliptin is able to delay the onset of diabetes in a type 1 diabetes model (NOD mouse). The pronounced distributed beta cell effects that can be observed in this animal model indicate that such inhibition of DPP-4 not only protects beta cells by increasing active GLP-1 levels, but may also exert direct or indirect anti-inflammatory actions.

权利要求:
Claims (6)
[0001]
1. Use of linagliptin, which is a DPP-4 inhibitor, characterized in that it is to prepare a subcutaneous or transdermal drug to treat a metabolic disease.
[0002]
2. Use according to claim 1, characterized in that the metabolic disease is type 2 diabetes.
[0003]
3. Use according to claim 1 or 2, characterized in that the drug is for once a day, alternate days, three times a week, twice a week or once a week.
[0004]
4. Pharmaceutical composition, characterized by the fact that it comprises: (a) linagliptin, which is a DPP-4 inhibitor; and (b) pharmaceutically acceptable carrier and/or diluent, wherein the pharmaceutical composition is a subcutaneous or transdermal composition.
[0005]
5. Pharmaceutical composition according to claim 4, characterized in that it further comprises a long-acting basal insulin.
[0006]
6. Pharmaceutical composition according to claim 5, characterized in that the long-acting basal insulin is selected from insulin detemir, insulin glargine and insulin degludec.

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法律状态:
2018-01-23| B07D| Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]|

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2018-04-10| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2019-01-29| B07E| Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]|Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |

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2019-06-11| B06T| Formal requirements before examination [chapter 6.20 patent gazette]|

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2020-09-15| B07A| Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]|

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2021-03-02| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2021-05-11| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/06/2011, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

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EP10167243|2010-06-24|

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EP10167243.4|2010-06-24|

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PCT/EP2011/060449|WO2011161161A1|2010-06-24|2011-06-22|Diabetes therapy|

---